The Cairo and Vincennes Railroad was a 19th-century American railroad that connected Cairo, Illinois, with Vincennes, Indiana. It was chartered by the state of Illinois in 1867 through the efforts of former American Civil War General Green B. Raum, who subsequently oversaw the planning and engineering of the proposed line. Within a few years, the fledgling railroad company named another former general, Ambrose Burnside, as its president. The Cairo & Vincennes began laying track in 1870 and completed the initial portion in 1872 to haul coal from southern Illinois mines. However, the route was not fully completed until late in 1874.