The Tsitsishvili (Georgian: ციციშვილი) is a Georgian noble family, with several notable members from the 15th century through the 20th. The Tsitsishvili family was a continuation of the medieval house of Panaskerteli, known in the province of Upper Kartli (Samtskhe) from the 12th century, who derived their name from the castle of Panaskerti in Tao-Klarjeti. They came into prominence with Zachariah of Panaskerti, who, together with some other nobles, put down in 1192 the revolt against Queen Tamar of Georgia and were eventually enfeoffed with the duchy of Tao. His descendant, T'aqa Panaskerteli, Duke of Tao, defeated the Turkomans invading Georgia in about 1302 at Tortomi Castle.