The 1910 Pittsburgh Panthers football team represented the University of Pittsburgh in the 1910 college football season. Pittsburgh shut out all nine of its opponents, outscored opponents by a combined score of 282 to 0, and finished with a perfect 9–0 record in their third year under head coach Joseph H. Thompson. The team has been recognized as a co-national champion of 1910 by the National Championship Foundation. Significant games included victories over West Virginia (38–0) and Penn State (11–0). Two Pittsburgh players were recognized by at least one selector on the 1910 College Football All-America Team. They are: fullback Tex Richards (Pittsburgh Dispatch, 1st team); and center Ralph Galvin (Pittsburgh Dispatch, 1st team; Pittsburgh Leader, 1st team).