The 2001 Calder Cup playoffs of the American Hockey League began on April 10, 2001. The sixteen teams that qualified, eight from each conference, played best-of-five series for division semifinals and best-of-seven series for division finals and conference finals. The conference champions played a best-of-seven series for the Calder Cup. The Calder Cup Final ended on May 28, 2001 with the Saint John Flames defeating the Wilkes-Barre/Scranton Penguins four games to two to win the first, and only, Calder Cup in team history.