Pozanicline
Pozanicline (INN, codenamed ABT-089) is a drug developed by Abbott, that has nootropic and neuroprotective effects. Animal studies suggested it useful for the treatment of ADHD and subsequent human trials have shown ABT-089 to be effective for this application. It binds with high affinity subtype-selective to the α4β2 nicotinic acetylcholine receptors and has partial agonism to the subtype, but not the α7 and α3β4 subtypes familiar to nicotine. It has particularly low tendency to cause side effects compared to other drugs in the class, making it an exciting candidate for clinical development.
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Pozanicline
Pozanicline (INN, codenamed ABT-089) is a drug developed by Abbott, that has nootropic and neuroprotective effects. Animal studies suggested it useful for the treatment of ADHD and subsequent human trials have shown ABT-089 to be effective for this application. It binds with high affinity subtype-selective to the α4β2 nicotinic acetylcholine receptors and has partial agonism to the subtype, but not the α7 and α3β4 subtypes familiar to nicotine. It has particularly low tendency to cause side effects compared to other drugs in the class, making it an exciting candidate for clinical development.
has abstract
Pozanicline (INN, codenamed AB ...... date for clinical development.
@en
CAS number
161417-03-4
FDA UNII code
CL2002R563
PubChem
Wikipage page ID
17,716,446
page length (characters) of wiki page
Wikipage revision ID
1,018,581,098
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ATC suffix
None
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CAS number
ChemSpiderID
IUPAC name
molecular weight
1.92258e+2
PubChem
SMILES
CC1=COC[C@@H]2CCCN2
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StdInChIKey
YRVIKLBSVVNSHF-JTQLQIEISA-N
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UNII
CL2002R563
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Verifiedfields
changed
@en
verifiedrevid
448,113,772
Watchedfields
changed
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wikiPageUsesTemplate
hypernym
comment
Pozanicline (INN, codenamed AB ...... date for clinical development.
@en
label
Pozanicline
@en