Prolyl isomerase
Prolyl isomerase (also known as peptidylprolyl isomerase or PPIase) is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but proline's unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains.
Cis-trans prolyl isomeraseEC 5.2.1.8PPIasePPlasePPlase domainPeptidyl-prolyl cis-trans isomerasePeptidyl-prolyl isomerasePeptidyl prolyl cis-trans-isomerasePeptidyl prolyl cis-trans isomerasePeptidyl prolyl cis/trans isomerasePeptidylproline cis-trans-isomerasePeptidylprolyl isomerasePeptidylprolylisomeraseProlylisomerase
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Biochemistry of Alzheimer's diseaseBruck syndromeChaperone (protein)Cis-trans prolyl isomeraseCyclophilinEC 5.2.1.8FKBPFKBP1AFKBP1BFKBP2FKBP3FKBP4FKBP7FKBP8ImmunophilinsIsomeraseList of EC numbers (EC 5)List of MeSH codes (D08)List of enzymesMethanococcoides burtoniiNKTRPPIBPPICPPIE (gene)PPIFPPIL1PPIasePPlasePPlase domainParvulinParvulin 14Peptidyl-prolyl cis-trans isomerasePeptidyl-prolyl isomerasePeptidyl prolyl cis-trans-isomerasePeptidyl prolyl cis-trans isomerasePeptidyl prolyl cis/trans isomerasePeptidylproline cis-trans-isomerasePeptidylprolyl isomerasePeptidylprolyl isomerase APeptidylprolyl isomerase D
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primaryTopic
Prolyl isomerase
Prolyl isomerase (also known as peptidylprolyl isomerase or PPIase) is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but proline's unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains.
has abstract
Les peptidyl prolyl isomérases ...... otéine (en) humaine (PDB 1NMW)
@fr
Peptidyl-Prolyl-cis-trans-Isom ...... ei Klassen eingeteilt: , und .
@de
Peptidyl-prolyl cis-trans izom ...... skládání kolagenu nezdržovalo.
@cs
Prolyl isomerase (also known a ...... tain prolyl isomerase domains.
@en
برويل ايسوميريز(بالإنجليزيةPro ...... توي على نطاق بروليل ايسوموريز.
@ar
プロリルイソメラーゼ(Prolyl isomerase、また ...... には、プロリルイソメラーゼ活性は直接関係しない可能性がある。
@ja
EC number
Wikipage page ID
page length (characters) of wiki page
Wikipage revision ID
993,320,523
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CAS number
EC number
GO code
InterPro
IPR000297
@en
IUBMB EC number
Membranome superfamily
name
Peptidyl-prolyl cis-trans isomerase, PpiC-type
@en
Peptidylprolyl isomerase
@en
Pfam
PF00639
@en
PROSITE
PDOC00840
@en
symbol
PPIase_PpiC
@en
wikiPageUsesTemplate
subject
hypernym
comment
Les peptidyl prolyl isomérases ...... otéine (en) humaine (PDB 1NMW)
@fr
Peptidyl-Prolyl-cis-trans-Isom ...... ei Klassen eingeteilt: , und .
@de
Peptidyl-prolyl cis-trans izom ...... skládání kolagenu nezdržovalo.
@cs
Prolyl isomerase (also known a ...... tain prolyl isomerase domains.
@en
برويل ايسوميريز(بالإنجليزيةPro ...... توي على نطاق بروليل ايسوموريز.
@ar
プロリルイソメラーゼ(Prolyl isomerase、また ...... ーゼはここで働き、従ってシャペロンの一つということができる。
@ja
label
Peptidyl-Prolyl-cis-trans-Isomerasen
@de
Peptidyl-prolyl cis-trans izomeráza
@cs
Peptidylprolyl isomérase
@fr
Prolyl isomerase
@en
برويل ايسوميريز
@ar
プロリルイソメラーゼ
@ja
sameAs
wasDerivedFrom
isPrimaryTopicOf
name
Peptidylprolyl isomerase
@en