about
P688
PML regulates p53 stability by sequestering Mdm2 to the nucleolusCARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnoverTrim24 targets endogenous p53 for degradationAIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathwayDefining the molecular basis of Arf and Hdm2 interactionsTargeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulationSUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineagesS6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage responseA mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial cleftingRegulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damagePhosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligaseEnhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-lessStabilization and activation of p53 induced by Cdk5 contributes to neuronal cell deathGenetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosisRegulation of ubiquitin ligase dynamics by the nucleolusImpaired p53 expression, function, and nuclear localization in calreticulin-deficient cellsA novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 InteractionPuma is required for p53-induced depletion of adult stem cellsMdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stressSynergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart developmentRibosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cellsRegulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.BAI1 regulates spatial learning and synaptic plasticity in the hippocampusMdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β.FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage.A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
P921
Q24296743-B2C128EB-46B6-4997-B2BA-EEB0F8D0A961Q24303502-E818A6F5-726D-4111-9A36-0A2ADF906464Q24306675-E84C831C-2803-4953-8A23-91188A826B53Q24316484-183EC161-9FB6-4F64-A127-4225B8EB3FB9Q24336311-B666F5D0-012C-46B2-BE1B-B49DBE150984Q24339423-AE743A54-1F87-4768-BABF-06E097F51231Q24644434-6F321F48-A9F1-42E7-8CD9-93FBF714C2ACQ24657777-104CC3E9-2E61-4D68-9803-DAD1A4C56477Q28506702-8229D2B2-E555-4B8A-82DF-492A2CC0BC09Q28507075-6D310088-3F26-44DB-9B72-25BD745DBC5CQ28508240-0D77F33A-15E7-4FEB-A97C-56BA86ED831AQ28508647-F8D79038-CF28-4B17-8F5A-B624BB8AC734Q28509658-3CCF3FC7-DE65-427B-B8DA-5D9ED1E6C3FBQ28509672-1BE68870-AA71-4DE1-9619-F27857884620Q28510160-308659EC-5279-4C74-8686-AF8CDCBB4884Q28511501-FEB72B1A-3CBC-4905-9EFB-6F02796A52A3Q28511549-2FD2DDE1-6E24-4855-A037-5D3DC79B29D8Q28585291-7746C2F4-1429-4542-BCF9-1EBD48DB814FQ28585867-E7497817-CC48-4381-AFF6-9E455A0C8999Q28586399-FF6A3517-E678-4EE9-87D6-475013B3B0E4Q28586586-74180F1D-C55B-4EF0-9987-5B5BBF926019Q28588691-BFE9F55F-02C1-4177-B179-030F9B93F10EQ28589774-03206B5B-A5C0-4E12-B822-2CAC11211FA3Q28590794-6F59074C-0CFA-4BD7-9694-AE66E67EE8D0Q28591824-60389F19-D022-45F8-879D-5B4A39E62DC2Q28592139-50CD44F1-ECBB-4B58-8473-DF07C29B84A4Q28593530-21F06251-146E-4BBB-814E-EA24D7088863Q28594772-9590A4DE-E64C-4139-BB40-A9EDD6D9ACE1Q28910201-347DA58A-AAAD-47C4-A3FD-9902C5A63D0AQ29976922-3AA5174A-BDD3-44A3-B021-93513046AE96Q33112266-C1CBC55D-87AA-430C-8BDE-D29569B1DC21Q35451059-D2C451D7-2538-4F61-9615-E6974BB66AAEQ39062387-B0FD9405-3DCD-4A53-95DA-16BD7053DF3FQ39905040-F43C83CD-4A68-455A-BC1D-2C1365B5BDA0
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Transformed mouse 3T3 cell double minute 2
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Transformed mouse 3T3 cell double minute 2
@en
Transformed mouse 3T3 cell double minute 2
@nl
type
label
Transformed mouse 3T3 cell double minute 2
@en
Transformed mouse 3T3 cell double minute 2
@nl
altLabel
E3 ubiquitin-protein ligase Mdm2
@en
Mdm2
@en
RING-type E3 ubiquitin transferase Mdm2
@en
double minute 2 protein
@en
oncoprotein Mdm2
@en
p53-binding protein Mdm2
@en
prefLabel
Transformed mouse 3T3 cell double minute 2
@en
Transformed mouse 3T3 cell double minute 2
@nl
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NP_001275515
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ENSMUSP00000020408
ENSMUSP00000100898
ENSMUSP00000137039