Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
about
New Insights into Wnt-Lrp5/6-β-Catenin Signaling in MechanotransductionProstaglandin E2 signals through PTGER2 to regulate sclerostin expressionBone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator functionOsteocyte control of bone formation via sclerostin, a novel BMP antagonistSOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorControl of the SOST bone enhancer by PTH using MEF2 transcription factorsSix novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone densityAutosomal dominant craniometaphyseal dysplasia is caused by mutations in the transmembrane protein ANKPolymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites.Pathogenesis of osteoporosis: concepts, conflicts, and prospectsLrp5 functions in bone to regulate bone massWnt modulators in the biotech pipelineDistinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathwaysWnt/beta-catenin signaling: components, mechanisms, and diseasesEffects of PTH on osteocyte functionThe amazing osteocyteOncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in miceHigh-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older menSclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonistIdentification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem diseaseSclerostin Antibody Therapy for the Treatment of Osteoporosis: Clinical Prospects and ChallengesSclerostin Inhibition in the Management of OsteoporosisFrom disease to treatment: from rare skeletal disorders to treatments for osteoporosisCatabolic and anabolic actions of parathyroid hormone on the skeletonImpact of inflammation on the osteoblast in rheumatic diseasesGenetic polymorphism in extracellular regulators of Wnt signaling pathwayWNT signaling in bone development and homeostasisThe osteocyte as a therapeutic target in the treatment of osteoporosisModulating Bone Resorption and Bone Formation in Opposite Directions in the Treatment of Postmenopausal OsteoporosisOsteoporosis and obesity: Role of Wnt pathway in human and murine modelsControl of bone mass and remodeling by PTH receptor signaling in osteocytesCharacterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATIONRapid phenotyping of knockout mice to identify genetic determinants of bone strengthCortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's DiseaseA 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch populationCbfa1/RUNX2 directs specific expression of the sclerosteosis gene (SOST)Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complexSingle-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibodyLoss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosisNew sequence variants associated with bone mineral density
P2860
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P2860
Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Increased bone density in scle ...... novel secreted protein (SOST)
@ast
Increased bone density in scle ...... novel secreted protein (SOST)
@en
Increased bone density in scle ...... novel secreted protein (SOST)
@en-gb
Increased bone density in scle ...... novel secreted protein (SOST)
@nl
type
label
Increased bone density in scle ...... novel secreted protein (SOST)
@ast
Increased bone density in scle ...... novel secreted protein (SOST)
@en
Increased bone density in scle ...... novel secreted protein (SOST)
@en-gb
Increased bone density in scle ...... novel secreted protein (SOST)
@nl
prefLabel
Increased bone density in scle ...... novel secreted protein (SOST)
@ast
Increased bone density in scle ...... novel secreted protein (SOST)
@en
Increased bone density in scle ...... novel secreted protein (SOST)
@en-gb
Increased bone density in scle ...... novel secreted protein (SOST)
@nl
P2093
P3181
P356
P1476
Increased bone density in scle ...... novel secreted protein (SOST)
@en
P2093
A F Paes-Alves
C Stratakis
D Foernzler
F G Dikkers
J Van Den Ende
K Lindpaintner
P304
P3181
P356
10.1093/HMG/10.5.537
P407
P577
2001-03-01T00:00:00Z