A conserved family of prolyl-4-hydroxylases that modify HIF
about
Nuclear localization of the mitochondrial factor HIGD1A during metabolic stressProlyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibitionOn the origin of Tibetans and their genetic basis in adapting high-altitude environmentsHypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxiaMammalian tumor suppressor Int6 specifically targets hypoxia inducible factor 2 alpha for degradation by hypoxia- and pVHL-independent regulationStructural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHLSUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaEvidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygenA yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinThe peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stabilityFIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factorIOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activityThe forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanismThe LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activityHypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alphaThe prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancerOxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHLSelective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathwaysStructure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alphaProlyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymesStructural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediatesErythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibitionRegulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive elementThe candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alphaBiochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasisVHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway.Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitinationScreening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia
P2860
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P2860
A conserved family of prolyl-4-hydroxylases that modify HIF
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
A conserved family of prolyl-4-hydroxylases that modify HIF
@ast
A conserved family of prolyl-4-hydroxylases that modify HIF
@en
A conserved family of prolyl-4-hydroxylases that modify HIF
@en-gb
A conserved family of prolyl-4-hydroxylases that modify HIF
@nl
type
label
A conserved family of prolyl-4-hydroxylases that modify HIF
@ast
A conserved family of prolyl-4-hydroxylases that modify HIF
@en
A conserved family of prolyl-4-hydroxylases that modify HIF
@en-gb
A conserved family of prolyl-4-hydroxylases that modify HIF
@nl
prefLabel
A conserved family of prolyl-4-hydroxylases that modify HIF
@ast
A conserved family of prolyl-4-hydroxylases that modify HIF
@en
A conserved family of prolyl-4-hydroxylases that modify HIF
@en-gb
A conserved family of prolyl-4-hydroxylases that modify HIF
@nl
P921
P3181
P356
P1433
P1476
A conserved family of prolyl-4-hydroxylases that modify HIF
@en
P2093
R K Bruick
S L McKnight
P304
P3181
P356
10.1126/SCIENCE.1066373
P407
P577
2001-11-09T00:00:00Z