Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease
about
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphataseThe phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseaseIdentification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAPCharacterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates.Phosphoinositides: tiny lipids with giant impact on cell regulationLoss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathyMutations in a P-type ATPase gene cause axonal degenerationPhosphoinositide regulation of integrin trafficking required for muscle attachment and maintenanceCaenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cellsStructure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidationCrystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate SpecificityGenetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathiesDual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membraneCongenital myopathies: diseases of the actin cytoskeleton.Identification of a novel SBF2 frameshift mutation in charcot-marie-tooth disease type 4B2 using whole-exome sequencing.Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting.Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1.Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functionsDisease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphateProtein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferationPhosphoinositide signaling disorders in human diseases.The myotubularin family of lipid phosphatases in disease and in spermatogenesisPtdIns5P: news and views of its appearance, disappearance and deeds.Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.Alternative mRNA fates identified in microRNA-associated transcriptome analysis.Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger.The CMT4B disease-causing phosphatases Mtmr2 and Mtmr13 localize to the Schwann cell cytoplasm and endomembrane compartments, where they depend upon each other to achieve wild-type levels of protein expression.Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.Endosomal phosphoinositides and human diseases.Phosphatidylinositolphosphate phosphatase activities and cancer.Following the trail of lipids: Signals initiated by PI3K function at multiple cellular membranes.The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2.Long-term effects of systemic gene therapy in a canine model of myotubular myopathy.MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.
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P2860
Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease
description
2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2002 թվականի փետրվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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name
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@ast
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en-gb
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@nl
type
label
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@ast
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en-gb
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@nl
prefLabel
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@ast
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en-gb
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@nl
P2093
P2860
P3181
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P1476
Myotubularin and MTMR2, phosph ...... 4B Charcot-Marie-Tooth disease
@en
P2093
Gregory S Taylor
Jack E Dixon
Knut M Torgersen
P2860
P304
P3181
P356
10.1074/JBC.M111087200
P407
P577
2002-02-08T00:00:00Z