Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
about
A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesisCHIP promotes Runx2 degradation and negatively regulates osteoblast differentiationTGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseOsteoarthritis pathogenesis: a review of molecular mechanismsTGF-β and BMP signaling in osteoblast differentiation and bone formationRegulation of gene expression in osteoblasts.The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradationHECT E3s and human disease.A positive role of microRNA-15b on regulation of osteoblast differentiation.Roles of E3 ubiquitin ligases in cell adhesion and migration.Inhibition of FOXO1/3 promotes vascular calcificationUbiquitin-dependent regulation of TGFbeta signaling in cancerSmurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation.Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α.The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.Signaling networks that control the lineage commitment and differentiation of bone cells.Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in miceSignaling and transcriptional regulation in osteoblast commitment and differentiationUbiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cellsMurine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2Transforming growth factor-beta signaling and ubiquitinators in cancer.Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migrationCyclin D1-cdk4 induce runx2 ubiquitination and degradation.PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation.Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.Up-regulation of BMP-2 antagonizes TGF-β1/ROCK-enhanced cardiac fibrotic signalling through activation of Smurf1/Smad6 complex.Regulating the stability of TGFbeta receptors and Smads.Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice.Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation.Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.Post-translational Regulation of Runx2 in Bone and Cartilage.Depletion of pro-oncogenic RUNX2 enhances gemcitabine (GEM) sensitivity of p53-mutated pancreatic cancer Panc-1 cells through the induction of pro-apoptotic TAp63.Smurf control in bone cells.WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.Regulation of bone and cartilage development by network between BMP signalling and transcription factors.Regulation of the transforming growth factor β pathway by reversible ubiquitylation.Control of osteogenesis by the canonical Wnt and BMP pathways in vivo: cooperation and antagonism between the canonical Wnt and BMP pathways as cells differentiate from osteochondroprogenitors to osteoblasts and osteocytes.A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.
P2860
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P2860
Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@ast
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en-gb
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@nl
type
label
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@ast
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en-gb
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@nl
prefLabel
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@ast
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en-gb
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@nl
P2093
P2860
P3181
P356
P1476
Smad6 interacts with Runx2 and ...... or 1-induced Runx2 degradation
@en
P2093
Hiroyuki Kaneki
Lianping Xing
Regis J O'keefe
Yong-Jun Wang
P2860
P304
P3181
P356
10.1074/JBC.M506761200
P407
P577
2006-02-10T00:00:00Z