Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases
about
Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitorsInactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humansChymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YBiochemical models of hereditary pancreatitisFramework for interpretation of trypsin-antitrypsin imbalance and genetic heterogeneity in pancreatitisThe P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activityActivation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells.A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitisHuman mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chainsAutoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression profiling and immunoassays identify pancreatic enzymes as a major target of the inflammatory process.Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis.Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.Whole organism transcriptome analysis of zebrafish models of Bardet-Biedl Syndrome and Alström Syndrome provides mechanistic insight into shared and divergent phenotypes.Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction.Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor.Genetic risk factors for pancreatic disorders.Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.The guinea pig pancreas secretes a single trypsinogen isoform, which is defective in autoactivation.Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girlInsights into the genetic risk factors for the development of pancreatic disease.Human trypsinogens in the pancreas and in cancer.Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen.Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli.Human cationic trypsinogen is sulfated on Tyr154.A Cohort Study of Adolescent and Midlife Diet and Pancreatic Cancer Risk in the NIH-AARP Diet and Health Study.Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1.Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitis.The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition.Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation.Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.Trypsinogen activation in acute and chronic pancreatitis: is it a prerequisite?Activation mechanism of recombinant Der p 3 allergen zymogen: contribution of cysteine protease Der p 1 and effect of propeptide glycosylation.Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes.Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test.Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
P2860
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P2860
Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@ast
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en-gb
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@nl
type
label
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@ast
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en-gb
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@nl
prefLabel
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@ast
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en-gb
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@nl
P2860
P921
P3181
P1433
P1476
Human anionic trypsinogen: pro ...... cations in pancreatic diseases
@en
P2093
Miklós Tóth
Zoltán Kukor
P2860
P304
P3181
P356
10.1046/J.1432-1033.2003.03581.X
P407
P577
2003-05-01T00:00:00Z