Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
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Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptorsThe adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factorsHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorMeasurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisalIdentification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transductionDeciphering the cross talk between hnRNP K and c-Src: the c-Src activation domain in hnRNP K is distinct from a second interaction siteMouse disabled (mDab1): a Src binding protein implicated in neuronal developmentSHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain.Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-KitRequirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathwaysMutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactionsTyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activationShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsAutophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell developmentFunctions and regulation of circular dorsal rufflesKit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferationRegulation of SRC family kinases in human cancersIdentifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinasesTargeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineagesMutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsGrowth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domainSrc family kinases are required for integrin but not PDGFR signal transduction.The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition.Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cellsBinding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis.A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation.Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway.SRC: a century of science brought to the clinic.VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomyPalmitoylation of p59fyn is reversible and sufficient for plasma membrane associationVascular endothelial growth factor receptors: molecular mechanisms of activation and therapeutic potentials.Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.
P2860
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P2860
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Identification of two juxtamem ...... th Src family tyrosine kinases
@ast
Identification of two juxtamem ...... th Src family tyrosine kinases
@en
Identification of two juxtamem ...... th Src family tyrosine kinases
@en-gb
Identification of two juxtamem ...... th Src family tyrosine kinases
@nl
type
label
Identification of two juxtamem ...... th Src family tyrosine kinases
@ast
Identification of two juxtamem ...... th Src family tyrosine kinases
@en
Identification of two juxtamem ...... th Src family tyrosine kinases
@en-gb
Identification of two juxtamem ...... th Src family tyrosine kinases
@nl
prefLabel
Identification of two juxtamem ...... th Src family tyrosine kinases
@ast
Identification of two juxtamem ...... th Src family tyrosine kinases
@en
Identification of two juxtamem ...... th Src family tyrosine kinases
@en-gb
Identification of two juxtamem ...... th Src family tyrosine kinases
@nl
P2093
P2860
P3181
P1433
P1476
Identification of two juxtamem ...... th Src family tyrosine kinases
@en
P2093
A Engström
C H Heldin
L Claesson-Welsh
L Rönnstrand
S A Courtneidge
P2860
P304
P3181
P407
P577
1993-06-01T00:00:00Z