p53 Stabilization and accumulation induced by human vaccinia-related kinase 1 - Wikidata - awgldk - TriplyDB

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

http://www.wikidata.org/entity/Q24314772

about

Plant and animal pathogen recognition receptors signal through non-RD kinases VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2 The vaccinia-related kinases phosphorylate the N' terminus of BAF, regulating its interaction with DNA and its retention in the nucleus Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1 VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop Biomarkers of head and neck cancer, tools or a gordian knot?Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site Global gene expression profiling of PAX-FKHR fusion-positive alveolar and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas Analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance Luteolin suppresses cancer cell proliferation by targeting vaccinia-related kinase 1 PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity.Human VRK1 is an early response gene and its loss causes a block in cell cycle progression.The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.Differential inhibitor sensitivity between human kinases VRK1 and VRK2.Functional disruption of the moloney murine leukemia virus preintegration complex by vaccinia-related kinases.Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.The changes of vaccinia related kinase 1 in grafted heart after rat heart transplantation VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence.Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells.

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p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

http://www.wikidata.org/entity/Q24314772

description

2004 nî lūn-bûn

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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@ast

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en-gb

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@nl

type

label

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@ast

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en-gb

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@nl

prefLabel

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@ast

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en-gb

p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@nl

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P3181

P356

MCB.24.23.10366-10380.2004

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Molecular and Cellular Biology

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p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

@en

P2093

Ana Sevilla

http://www.w3.org/2001/XMLSchema#string

Francisco M Vega

http://www.w3.org/2001/XMLSchema#string

Pedro A Lazo

http://www.w3.org/2001/XMLSchema#string

P2860

MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase

The protein kinase complement of the human genome

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

A dynamic role of HAUSP in the p53-Mdm2 pathway

The ubiquitin ligase COP1 is a critical negative regulator of p53

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

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10366-80

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scholarly article

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533098

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10.1128/MCB.24.23.10366-10380.2004

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23

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24

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2004-12-01T00:00:00Z

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225148592

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15542844

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529057

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