The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
about
Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexinIn vitro nuclear interactome of the HIV-1 Tat proteinStructures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAPStructure of the nuclear transport complex karyopherin-beta2-Ran x GppNHpEvidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAPThe GTPase-activating protein Rap1GAP uses a catalytic asparagineActivating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesisThe structure of mammalian serine racemase: evidence for conformational changes upon inhibitor bindingStructure and function of the intracellular region of the plexin-b1 transmembrane receptorThe retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysisSynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neuronsMechanism of the spatio-temporal regulation of Ras and Rap1.GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteinsBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityRetroviral oncogenes: a historical primerThe activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondiiBiological phosphoryl-transfer reactions: understanding mechanism and catalysisABC transporters: the power to changeThe Catalogue of Somatic Mutations in Cancer (COSMIC)Crystal structure of the GTPase-activating protein-related domain from IQGAP1The centaurin gamma-1 GTPase-like domain functions as an NTPaseSolution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1Self-renewal of embryonic stem cells by a small moleculeKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentSimilar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistanceRegulation of small GTPases by GEFs, GAPs, and GDIsOxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical studentsThe universally conserved prokaryotic GTPasesActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsA novel role for the GTPase-activating protein Bud2 in the spindle position checkpointThree conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transportStructure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complexGuanosine triphosphatase stimulation of oncogenic Ras mutantsStructure of the small G protein Rap2 in a non-catalytic complex with GTPTriphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanismThe crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis
P2860
Q21128780-0720BB82-9295-435D-BE88-EBC800FF5D91Q21245051-9BC799E3-39AE-4124-B4D5-A9A265389568Q22008518-AAD5F72C-F915-4F56-95A4-F23DDC6C3644Q22009923-D7D05A50-C7A7-42D3-B177-0CCD912E564FQ22254035-0D3F56BD-2F18-42DB-9469-DD98DCB13E92Q22254280-6522BFC3-16E7-416B-8973-2EA9285690D2Q24293002-F28C2FB4-F938-4A05-BEBB-B6AB80FD2113Q24294030-7E9FE7D3-5294-45B2-8B4D-1EFEF2F5B98BQ24297646-ECB3E505-2137-449E-BF8C-3303BF1E261DQ24309186-EC0E8B20-FEFC-45AD-80D8-72112C2D5CF7Q24315798-5FE433D8-BC30-4A24-ADA5-20CC0DFC9352Q24318951-DAFE6512-211B-45FF-B6A0-A9DC2AA75EDCQ24528111-4D20220C-4406-408F-8DFF-37E6E3D56752Q24545222-58106337-AAC8-439B-A739-C3FF7FB60495Q24545607-6349AAC1-612A-4192-B04B-A814F18BEE3AQ24551119-9D1DFEA5-2839-4D27-B9BD-7980AE6C12A1Q24563018-29ED06AA-7DE4-46AA-B3C8-012C37303641Q24611142-EA8C15E8-B75E-475C-9DA0-5505903EA698Q24617222-B2D4A079-CF2F-4B46-AC83-2D875E7C4739Q24617627-CB75370A-84F7-4E63-9C57-9C970A7B005DQ24634548-F79AADBB-6E5D-4378-AFAE-B96FD051474BQ24653244-21208597-0C4D-4E28-9981-B93A02C3E397Q24657246-1690B984-A0A1-49DF-8A72-B3AA1DA97F55Q24672233-80CA7599-0BD6-4742-AB56-25335DCAA1EAQ24672521-18C2F0C1-BA39-4FA4-A791-CB88859FD1F0Q24676820-9A88CD5B-38C0-4DD0-955E-09FF4F8A1A5EQ26751520-CE757101-6315-4D50-874B-2898901129F0Q26795609-A550E23B-B9D4-40A7-BEB7-3234C53C2F95Q26825750-B62F67B3-B7F8-4E5F-A8D0-131E19636CE8Q26998478-69EC2ED4-8A08-4F1D-A245-6DED0C46FA64Q27021480-8FF3132A-A1CD-43A8-AFA3-88469BDB6A0AQ27027458-5389C631-28F0-4F2F-87CE-9D4AE2A0773FQ27303794-B31EA268-F42F-45E3-BCD6-0FA57F02B792Q27490905-EE820DEF-C361-461D-AA54-33616A50A66BQ27617536-2C62CFFA-41CE-40DC-9BD1-38572A6448D1Q27618485-52A942AF-378F-4D4B-A5DB-5E7AB416C6F3Q27618496-E1921762-A9BC-4B80-8B12-9FF9EBA37635Q27620631-057CE71F-07B4-41B0-9EFB-E660EDC2C572Q27626880-4D072869-FC69-4585-94ED-01FDBCCC6C00Q27626968-3BABD611-D3DD-42D2-9A89-79D606DC3BFF
P2860
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
description
1997 nî lūn-bûn
@nan
1997 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@ast
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en-gb
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@nl
type
label
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@ast
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en-gb
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@nl
prefLabel
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@ast
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en-gb
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@nl
P2093
P3181
P1433
P1476
The Ras-RasGAP complex: struct ...... loss in oncogenic Ras mutants
@en
P2093
A Lautwein
A Wittinghofer
K Scheffzek
L Wiesmüller
M R Ahmadian
P3181
P356
10.1126/SCIENCE.277.5324.333
P407
P577
1997-07-18T00:00:00Z