TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
about
ADCY5 couples glucose to insulin secretion in human isletsDecreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionGenome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetesThe association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysisThe required beta cell research for improving treatment of type 2 diabetesInsulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsClass II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cellsTCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention programProgression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps.β-Cell failure in type 2 diabetes.Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetesType 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146.An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cellsHypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cellsLKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization.Effects of rs7903146 variation in the Tcf7l2 gene in the lipid metabolism of three different populationsThe pancreatic β cell: recent insights from human genetics.TCF7L2 is a master regulator of insulin production and processing.Diabetes mellitus: The epidemic of the century.The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cellsA role for SPARC in the moderation of human insulin secretionCharacterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation.The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis.Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in miceAn alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes.Inherited β-cell dysfunction in lean individuals with type 2 diabetes.Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.Islet autoantigens: structure, function, localization, and regulation.Implications of polyadenylation in health and disease.The role of the Wnt signaling pathway in incretin hormone production and function.Review of the neuroanatomic landscape implicated in glucose sensing and regulation of nutrient signaling: immunophenotypic localization of diabetes gene Tcf7l2 in the developing murine brain.The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspectiveGeniposide promotes beta-cell regeneration and survival through regulating β-catenin/TCF7L2 pathway
P2860
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P2860
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@ast
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en-gb
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@nl
type
label
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@ast
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en-gb
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@nl
prefLabel
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@ast
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en-gb
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
@en
P2093
Angela McDonald
Guy A Rutter
Katrin Kronenberger
Merewyn K Loder
Raffaella Carzaniga
P2860
P304
P3181
P356
10.2337/DB08-1187
P407
P577
2009-04-01T00:00:00Z