Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption
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TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repressionPML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infectionsDifferential role of Sp100 isoforms in interferon-mediated repression of herpes simplex virus type 1 immediate-early protein expressionHuman cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expressionProteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodiesICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cellsThe Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressorAbility of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cellsThe herpes simplex virus ICP0 RING finger domain inhibits IRF3- and IRF7-mediated activation of interferon-stimulated genesPML residue lysine 160 is required for the degradation of PML induced by herpes simplex virus type 1 regulatory protein ICP0The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5aSUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damageThe Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral GenomesHSV-1 ICP0: paving the way for viral replicationRole of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradationEbola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machineryA viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defenceKaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivationRegulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone.Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation.Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresisA manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics.The chicken adenovirus Gam1 protein, an inhibitor of the sumoylation pathway, partially complements ICP0-null mutant herpes simplex virus 1ICP0 induces the accumulation of colocalizing conjugated ubiquitin.Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific.Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureHerpes simplex virus ICP0 mutants are hypersensitive to interferonCovalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10)Sumoylation of the Epstein-Barr virus BZLF1 protein inhibits its transcriptional activity and is regulated by the virus-encoded protein kinase.Exon 3 of the human cytomegalovirus major immediate-early region is required for efficient viral gene expression and for cellular cyclin modulation.Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate ImmunityDeconstructing PML-induced premature senescence.SUMO-1 modification of human cytomegalovirus IE1/IE72Herpes simplex virus selectively induces expression of the CC chemokine RANTES/CCL5 in macrophages through a mechanism dependent on PKR and ICP0Regulation of Sp100A subnuclear localization and transcriptional function by EBNA-LP and interferon.
P2860
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P2860
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Viral immediate-early proteins ...... g with nuclear body disruption
@ast
Viral immediate-early proteins ...... g with nuclear body disruption
@en
Viral immediate-early proteins ...... g with nuclear body disruption
@en-gb
Viral immediate-early proteins ...... g with nuclear body disruption
@nl
type
label
Viral immediate-early proteins ...... g with nuclear body disruption
@ast
Viral immediate-early proteins ...... g with nuclear body disruption
@en
Viral immediate-early proteins ...... g with nuclear body disruption
@en-gb
Viral immediate-early proteins ...... g with nuclear body disruption
@nl
prefLabel
Viral immediate-early proteins ...... g with nuclear body disruption
@ast
Viral immediate-early proteins ...... g with nuclear body disruption
@en
Viral immediate-early proteins ...... g with nuclear body disruption
@en-gb
Viral immediate-early proteins ...... g with nuclear body disruption
@nl
P2860
P3181
P1433
P1476
Viral immediate-early proteins ...... g with nuclear body disruption
@en
P2093
P2860
P304
P3181
P407
P577
1999-06-01T00:00:00Z