Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
about
The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKREndoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaPACT, a protein activator of the interferon-induced protein kinase, PKR.Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPKProtein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein.Molecular basis for PKR activation by PACT or dsRNAModular structure of PACT: distinct domains for binding and activating PKRRAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infectionImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionThe double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitroNuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinaseStimulation of interferon regulatory factor-1 by prolactinEnhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKRThe direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formationPhosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosisSerine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibitionActivation of target-tissue immune-recognition molecules by double-stranded polynucleotidesPKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cellsSignal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1Requirement of PKR dimerization mediated by specific hydrophobic residues for its activation by double-stranded RNA and its antigrowth effects in yeastMechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr geneDouble-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18Serine phosphorylation of STATs.Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.The protein kinase PKR: a molecular clock that sequentially activates survival and death programs.Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicinDouble-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells.Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modificationThe antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouseInhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infectionInterferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.Enhanced phosphorylation of STAT-1 is dependent on double-stranded RNA-dependent protein kinase signaling in HLA-B27-expressing U937 monocytic cells.Translational control in T lymphocytes.Effects of length and location on the cellular response to double-stranded RNA.
P2860
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P2860
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Physical association between S ...... tranded RNA signaling pathways
@ast
Physical association between S ...... tranded RNA signaling pathways
@en
Physical association between S ...... tranded RNA signaling pathways
@en-gb
Physical association between S ...... tranded RNA signaling pathways
@nl
type
label
Physical association between S ...... tranded RNA signaling pathways
@ast
Physical association between S ...... tranded RNA signaling pathways
@en
Physical association between S ...... tranded RNA signaling pathways
@en-gb
Physical association between S ...... tranded RNA signaling pathways
@nl
prefLabel
Physical association between S ...... tranded RNA signaling pathways
@ast
Physical association between S ...... tranded RNA signaling pathways
@en
Physical association between S ...... tranded RNA signaling pathways
@en-gb
Physical association between S ...... tranded RNA signaling pathways
@nl
P2093
P2860
P356
P1433
P1476
Physical association between S ...... tranded RNA signaling pathways
@en
P2093
Cuddihy AR
Kirchhoff S
Koromilas AE
P2860
P304
P356
10.1093/EMBOJ/16.6.1291
P407
P577
1997-03-01T00:00:00Z