p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein
about
Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuliSignal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signalingCRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cellsJAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal regionKit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferationThe MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-KitInteractions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factorEvidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptorSHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substratesPlatelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell typesA novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors.IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation.Control of B cell development by Ras-mediated activation of Raf.The human granulocyte-macrophage colony-stimulating factor receptor is capable of initiating signal transduction in NIH3T3 cells.Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase.FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.Blocking oncogenic Ras signaling for cancer therapy.Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responsesCommon elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.Interleukin 2 activates extracellular signal-regulated protein kinase 2.Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating alleleDissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation.Mitogenic activation of the Ras guanine nucleotide exchange factor in NIH 3T3 cells involves protein tyrosine phosphorylationInterleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway.Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglyceridesOncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.Structural aspects of receptor dimerization. c-kit as an example.Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras.c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.MAP kinase activation by interleukin-9 in lymphoid and mast cell lines.Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in Kit. Role for Src kinase pathway in Kit-induced cooperation with erythropoietin receptor.The enigma of cytokine redundancy.Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.Coexpression of c-kit and stem cell factor in breast cancer results in enhanced sensitivity to members of the EGF family of growth factors.Investigation of the molecular mechanisms underlying growth factor synergy: the role of ERK 2 activation in synergy.
P2860
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P2860
p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein
description
1992 nî lūn-bûn
@nan
1992 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի մարտին հրատարակված գիտական հոդված
@hy
1992年の論文
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1992年学术文章
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1992年学术文章
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1992年学术文章
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1992年学术文章
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1992年学术文章
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1992年學術文章
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name
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@ast
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@en
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@nl
type
label
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@ast
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@en
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@nl
prefLabel
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@ast
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@en
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@nl
P2093
P2860
P921
P356
P1476
p21ras activation via hemopoie ...... 1ras GTPase-activating protein
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.5.1587
P407
P577
1992-03-01T00:00:00Z