Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
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Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine developmentImmunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected ErythrocytesThe role of animal models for research on severe malariaDifferential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSADimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARCStructural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum RosettingModeling cytoadhesion of Plasmodium falciparum-infected erythrocytes and leukocytes-common principles and distinctive featuresMalaria Parasites: The Great EscapeAn image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytesVar2CSA minimal CSA binding region is located within the N-terminal regionTargeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacityIdentification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells.Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria.Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions.Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolatesIron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death.Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region.Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteinsSequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domainsDesigning a VAR2CSA-based vaccine to prevent placental malaria.Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA.Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins.Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced.A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins.The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding siteHow specific is Plasmodium falciparum adherence to chondroitin 4-sulfate?High-throughput screening platform identifies small molecules that prevent sequestration of Plasmodium falciparum-infected erythrocytes.Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, BeninParity-dependent recognition of DBL1X-3X suggests an important role of the VAR2CSA high-affinity CSA-binding region in the development of the humoral response against placental malaria.Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo.Transcription of var genes other than var2csa in Plasmodium falciparum parasites infecting Mozambican pregnant women.Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment FcμStructural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactionsInfluence of Intermittent Preventive Treatment on Antibodies to VAR2CSA in Pregnant Cameroonian WomenIdentification of VAR2CSA domain-specific inhibitory antibodies of the Plasmodium falciparum erythrocyte membrane protein 1 using a novel flow cytometry assayChondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.Pregnancy malaria: cryptic disease, apparent solution.
P2860
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P2860
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Full-length extracellular regi ...... , high-affinity binding to CSA
@ast
Full-length extracellular regi ...... , high-affinity binding to CSA
@en
Full-length extracellular regi ...... , high-affinity binding to CSA
@nl
type
label
Full-length extracellular regi ...... , high-affinity binding to CSA
@ast
Full-length extracellular regi ...... , high-affinity binding to CSA
@en
Full-length extracellular regi ...... , high-affinity binding to CSA
@nl
prefLabel
Full-length extracellular regi ...... , high-affinity binding to CSA
@ast
Full-length extracellular regi ...... , high-affinity binding to CSA
@en
Full-length extracellular regi ...... , high-affinity binding to CSA
@nl
P2093
P2860
P50
P3181
P356
P1476
Full-length extracellular regi ...... , high-affinity binding to CSA
@en
P2093
Alexandre Juillerat
Benoît Gamain
Bruno Baron
Graham A Bentley
Grazyna Faure
Hassan Belrhali
Saurabh Kumar Singh
Stéphane Gangnard
Stéphanie Ramboarina
Sébastien Dechavanne
P2860
P304
P3181
P356
10.1073/PNAS.1000951107
P407
P577
2010-03-16T00:00:00Z