High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design
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Rapid sampling of molecular motions with prior information constraintsStructure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding AffinitiesRational stabilization of enzymes by computational redesign of surface charge-charge interactionsA De Novo Protein Binding Pair By Computational Design and Directed EvolutionIncreasing Sequence Diversity with Flexible Backbone Protein Design: The Complete Redesign of a Protein Hydrophobic CoreAn integrated approach for thermal stabilization of a mesophilic adenylate kinaseComputational Redesign of Thioredoxin Is Hypersensitive toward Minor Conformational Changes in the Backbone TemplateThe molecular basis of conformational instability of the ecdysone receptor DNA binding domain studied by in silico and in vitro experimentsScientific benchmarks for guiding macromolecular energy function improvementDirect prediction of profiles of sequences compatible with a protein structure by neural networks with fragment-based local and energy-based nonlocal profilesRational design of α-helical tandem repeat proteins with closed architecturesTemplate-based protein modeling: recent methodological advances.Practically useful: what the Rosetta protein modeling suite can do for youAchievements and Challenges in Computational Protein Design.Role of conformational sampling in computing mutation-induced changes in protein structure and stabilityComputational protein design and large-scale assessment by I-TASSER structure assembly simulationsConformational diversity and computational enzyme designPredicting positive p53 cancer rescue regions using Most Informative Positive (MIP) active learning.Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).Computational design of second-site suppressor mutations at protein-protein interfacesA peptide antagonist of the TLR4-MD2 interaction.Identification of interacting hot spots in the beta3 integrin stalk using comprehensive interface designImproving computational protein design by using structure-derived sequence profile.Engineering a more thermostable blue light photo receptor Bacillus subtilis YtvA LOV domain by a computer aided rational design method.Computational protein design: Advances in the design and redesign of biomolecular nanostructuresAn evolution-based approach to De Novo protein design and case study on Mycobacterium tuberculosis.Transmembrane peptides used to investigate the homo-oligomeric interface and binding hotspot of latent membrane protein 1.Application of Enhanced Sampling Monte Carlo Methods for High-Resolution Protein-Protein Docking in Rosetta.Automated selection of stabilizing mutations in designed and natural proteins.Redesign of the monomer-monomer interface of Cre recombinase yields an obligate heterotetrameric complex.A critical analysis of computational protein design with sparse residue interaction graphs.A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function.Computational design of the Fyn SH3 domain with increased stability through optimization of surface charge charge interactionsFast, cheap and out of control--Insights into thermodynamic and informatic constraints on natural protein sequences from de novo protein design.Energy functions in de novo protein design: current challenges and future prospects.Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface.Computational protein design with explicit consideration of surface hydrophobic patches.Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) × c-MET Antibodies and Antibody-Drug Conjugates.Collective repacking reveals that the structures of protein cores are uniquely specified by steric repulsive interactions.Comparison of Five Protein Engineering Strategies for Stabilizing an α/β-Hydrolase.
P2860
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P2860
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
High-resolution structural and ...... y computational protein design
@ast
High-resolution structural and ...... y computational protein design
@en
High-resolution structural and ...... y computational protein design
@nl
type
label
High-resolution structural and ...... y computational protein design
@ast
High-resolution structural and ...... y computational protein design
@en
High-resolution structural and ...... y computational protein design
@nl
altLabel
High-resolution Structural and ...... y Computational Protein Design
@en
prefLabel
High-resolution structural and ...... y computational protein design
@ast
High-resolution structural and ...... y computational protein design
@en
High-resolution structural and ...... y computational protein design
@nl
P2093
P2860
P50
P1476
High-resolution structural and ...... y computational protein design
@en
P2093
Colin Corrent
Ethan A Merritt
James J Havranek
Ziad M Eletr
P2860
P304
P356
10.1016/J.JMB.2006.11.080
P407
P577
2007-03-02T00:00:00Z