IMP dehydrogenase: structure, mechanism, and inhibition.
about
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymesIdentification of novel Mt-Guab2 inhibitor series active against M. tuberculosisThe Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor SelectivityBacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound ComplexesDe novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformansThe AEROPATH project targetingPseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discoveryStructure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenaseOptimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate DehydrogenaseIncreased riboflavin production by manipulation of inosine 5'-monophosphate dehydrogenase in Ashbya gossypiiCrystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulationThe Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Undercover: gene control by metabolites and metabolic enzymesA screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenaseTriazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosisSuppressing dengue-2 infection by chemical inhibition of Aedes aegypti host factors.Two classes of bacterial IMPDHs according to their quaternary structures and catalytic propertiesMycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular CompoundsNovel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host AnimalsIdentification and Functional Analysis of the Mycophenolic Acid Gene Cluster of Penicillium roquefortiNovel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screenThe antibiotic potential of prokaryotic IMP dehydrogenase inhibitorsComprehensive analysis of type 1 fimbriae regulation in fimB-null strains from the multidrug resistant Escherichia coli ST131 clone.Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesisStructural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases.The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.Inosine monophosphate dehydrogenase expression and activity are significantly lower in kidney transplant recipients with diabetes mellitus.A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungiChemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus.Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors.A genome-wide screen identifies yeast genes required for tolerance to technical toxaphene, an organochlorinated pesticide mixtureA novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.In silico design of human IMPDH inhibitors using pharmacophore mapping and molecular docking approachesKinetically controlled drug resistance: how Penicillium brevicompactum survives mycophenolic acidStructure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogasterAdaptive evolution of drug targets in producer and non-producer organisms.New X-chromosomal interactors of dFMRP regulate axonal and synaptic morphology of brain neurons in Drosophila melanogaster
P2860
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P2860
IMP dehydrogenase: structure, mechanism, and inhibition.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
IMP dehydrogenase: structure, mechanism, and inhibition
@nl
IMP dehydrogenase: structure, mechanism, and inhibition.
@ast
IMP dehydrogenase: structure, mechanism, and inhibition.
@en
type
label
IMP dehydrogenase: structure, mechanism, and inhibition
@nl
IMP dehydrogenase: structure, mechanism, and inhibition.
@ast
IMP dehydrogenase: structure, mechanism, and inhibition.
@en
prefLabel
IMP dehydrogenase: structure, mechanism, and inhibition
@nl
IMP dehydrogenase: structure, mechanism, and inhibition.
@ast
IMP dehydrogenase: structure, mechanism, and inhibition.
@en
P2860
P3181
P356
P1433
P1476
IMP dehydrogenase: structure, mechanism, and inhibition.
@en
P2093
Lizbeth Hedstrom
P2860
P304
P3181
P356
10.1021/CR900021W
P407
P577
2009-07-01T00:00:00Z