PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
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Phosphatidylinositol 3,5-bisphosphate: low abundance, high significanceLipid kinases as therapeutic targets for chronic painPhosphoinositides in the mammalian endo-lysosomal networkInhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell deathEarly mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected miceNeuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channelsMechanisms of specificity in neuronal activity-regulated gene transcriptionDifferent subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytesAlterations of Ca(v)1.2 and 5-hydroxytryptamine in rat hearts after positional asphyxia.Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons.Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)PDevelopment of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6.Fig4 deficiency: a newly emerged lysosomal storage disorder?Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.Trafficking and stability of voltage-gated calcium channels.The changing landscape of voltage-gated calcium channels in neurovascular disorders and in neurodegenerative diseasesThe role of phosphoinositides in synapse function.Modeling the Attractor Landscape of Disease Progression: a Network-Based Approach.The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.Activity-dependent regulation of T-type calcium channels by submembrane calcium ionsPI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.New insights into the functions of PtdIns(3,5)P2 in the pathogenisis of neurodegenerative disorders.Up-regulation of the inwardly rectifying K⁺ channel Kir2.1 (KCNJ2) by protein kinase B (PKB/Akt) and PIKfyve.Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes.Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.
P2860
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P2860
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@ast
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@en
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@nl
type
label
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@ast
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@en
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@nl
prefLabel
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@ast
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@en
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@nl
P2860
P356
P1476
PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death
@en
P2093
Fuminori Tsuruta
Ricardo E Dolmetsch
P2860
P304
P356
10.1083/JCB.200903028
P407
P577
2009-10-01T00:00:00Z