beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
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A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPasesPhospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signalingThe diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphologyApproaches of targeting Rho GTPases in cancer drug discoveryDiacylglycerol Kinases in T Cell Tolerance and Effector FunctionChimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domainPhorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptorDynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activityGonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-srcRac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerinCloning and characterization of diacylglycerol kinase iota splice variants in rat brainCoordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.p23/Tmp21 associates with protein kinase Cdelta (PKCdelta) and modulates its apoptotic function.Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein.p23/Tmp21 differentially targets the Rac-GAP beta2-chimaerin and protein kinase C via their C1 domainsA novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylationEyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters.Membrane targeting by C1 and C2 domains.Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton.Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structureThe zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development.Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse.Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosisPKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors.Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and FunctionDiacylglycerol kinases in immune cell function and self-tolerance.A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.The many hats of protein kinase Cδ: one enzyme with many functions.β3-chimaerin, a novel member of the chimaerin Rac-GAP family.Signaling cascade of diacylglycerol kinase β in the pituitary intermediate lobe: dopamine D2 receptor/phospholipase Cβ4/diacylglycerol kinase β/protein kinase CαTranscriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1.PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2.O-Silylated C3-halohydrins as a novel class of protected building blocks for total, regio- and stereocontrolled synthesis of glycerolipid frameworks.Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions.4alpha-Phorbol negates the inhibitory effects of phorbol-12-myristate-13-acetate on human cilia and alters the phosphorylation of PKC.RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.
P2860
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P2860
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@ast
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@en
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@nl
type
label
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@ast
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@en
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@nl
prefLabel
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@ast
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@en
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@nl
P2093
P2860
P50
P3181
P356
P1476
beta2-chimaerin is a novel tar ...... igand binding to its C1 domain
@en
P2093
B Bienfait
M G Kazanietz
M L Garcia-Bermejo
P M Blumberg
V E Marquez
P2860
P304
11854-11859
P3181
P356
10.1073/PNAS.96.21.11854
P407
P577
1999-10-01T00:00:00Z