The Mediator complex: a master coordinator of transcription and cell lineage development
about
On the way of revealing coactivator complexes cross-talk during transcriptional activationMediator kinase module and human tumorigenesisCDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in DrosophilaT-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organsAssessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesSEA: a super-enhancer archive.Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs.The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator.Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cellsMED30 Regulates the Proliferation and Motility of Gastric Cancer Cells.Mediator subunit Med12 contributes to the maintenance of neural stem cell identity.Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency.Novel de novo heterozygous loss-of-function variants in MED13L and further delineation of the MED13L haploinsufficiency syndrome.The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.Super Enhancers in Cancers, Complex Disease, and Developmental Disorders.Evolution of disorder in Mediator complex and its functional relevanceMediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development.Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange SyndromeAuxin-dependent compositional change in Mediator in ARF7- and ARF19-mediated transcription.Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types.'Mediator-ing' messenger RNA processing.Eukaryotic enhancers: common features, regulation, and participation in diseases.The oxygenase Jmjd6--a case study in conflicting assignments.ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.Inducible super-enhancers are organized based on canonical signal-specific transcription factor binding elements.Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells.Inhibitors of cyclin-dependent kinases as cancer therapeutics.EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.A Novel Epi-drug Therapy Based on the Suppression of BET Family Epigenetic Readers.Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.Mechanisms and Developmental Roles of Promoter-proximal Pausing of RNA Polymerase II.Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure.Relating protein functional diversity to cell type number identifies genes that determine dynamic aspects of chromatin organisation as potential contributors to organismal complexity.MED23: a new Mediator of H2B monoubiquitylation.The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage.CDK8 Kinase Activity Promotes Glycolysis.Development and connectivity of the habenular nuclei.
P2860
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P2860
The Mediator complex: a master coordinator of transcription and cell lineage development
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
The Mediator complex: a master coordinator of transcription and cell lineage development
@ast
The Mediator complex: a master coordinator of transcription and cell lineage development
@en
The Mediator complex: a master coordinator of transcription and cell lineage development
@nl
type
label
The Mediator complex: a master coordinator of transcription and cell lineage development
@ast
The Mediator complex: a master coordinator of transcription and cell lineage development
@en
The Mediator complex: a master coordinator of transcription and cell lineage development
@nl
prefLabel
The Mediator complex: a master coordinator of transcription and cell lineage development
@ast
The Mediator complex: a master coordinator of transcription and cell lineage development
@en
The Mediator complex: a master coordinator of transcription and cell lineage development
@nl
P3181
P356
P1433
P1476
The Mediator complex: a master coordinator of transcription and cell lineage development
@en
P2093
Jing-wen Yin
P304
P3181
P356
10.1242/DEV.098392
P407
P50
P577
2014-03-01T00:00:00Z