Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects
about
Regulation of RNA binding proteins in trypanosomatid protozoan parasitesThe Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi InfectionDevelopment of a Bioluminescent Nitroreductase Probe for Preclinical ImagingTrypanothione reductase: a target protein for a combined in vitro and in silico screening approachIdentification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic TrypanosomatidsDrug resistance in eukaryotic microorganisms.Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids.New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain InhibitorsScreening and Identification of Inhibitors of Trypanosoma brucei Cathepsin L with Antitrypanosomal ActivityDibenzylideneacetones Are Potent Trypanocidal Compounds That Affect the Trypanosoma cruzi Redox SystemLimited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategyAnti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitorsEngineered P450 biocatalysts show improved activity and regio-promiscuity in aromatic nitration.Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infectionPentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomesThe anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasisChallenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host.Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.Evaluating 5-Nitrothiazoles as Trypanocidal Agents.Azoreductases in drug metabolism.Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group.Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.Synthesis and In Vitro Anti Leishmania amazonensis Biological Screening of Morita-Baylis-Hillman Adducts Prepared from Eugenol, Thymol and Carvacrol.Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.Effects of (1E,4E)-2-Methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one on Trypanosoma cruzi and Its Combinational Effect with Benznidazole, Ketoconazole, or Fluconazole.The N-myristoylome of Trypanosoma cruzi.Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds.The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids.In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series.SRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells.Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines.Challenging the Drug-Likeness Dogma for New Drug Discovery in TuberculosisNovel lead compounds in pre-clinical development against African sleeping sickness
P2860
Q26765180-2D720A05-4824-42EB-905A-013383E88E15Q26829884-FE5D9689-A34F-4AF8-B9E7-C48C7A1D4F13Q27303746-91B8115D-90CA-44C2-A230-41252AFD78D5Q28547882-5FDD31AF-22BA-4E1A-B5E6-39F67ECA753AQ28551301-9CE7E0E0-32A8-4DB9-88B1-3C9F8D09DDF1Q30248243-D3FFD50E-CC3C-48D0-9F1C-1FCFD280FF7BQ30274930-39CF0E52-DC58-4E4C-A3E9-B7F813157BEFQ30417002-BCC57D20-873E-411E-B6FB-C3273344773FQ33553551-301C49D1-B990-4041-956F-5297F14ABAC6Q35691038-FE27A52B-1A93-470A-B87E-CA6D4FB5121DQ35737729-F200933E-5C53-4D2D-8BA6-91376D43ED8DQ35848992-0B79F1F5-6A02-41F7-8CEB-ACB67822876FQ35859935-EF07174B-E24C-453E-A05A-582F97CBB655Q36158447-EC9386DF-7F65-442E-B21B-E01B8683A595Q36286306-FA45BBF4-BB66-46F6-96EB-36F8C8E798F1Q36345370-D4C9148B-641E-40FD-80C5-9D6D31DE1AEAQ36385616-F63577E5-415C-48F2-945A-699631D00460Q36684151-C2752E71-0DCB-41C7-832B-574B83D8B426Q36932080-570A4708-5DB7-4A60-857D-B3C303CD681EQ37670897-919FFDEF-3155-42C1-A29A-E206C88F3149Q38270529-77F1A6A1-8115-40AF-A52E-52AF4ED9A2ACQ38367643-289C249E-1F4A-4444-8982-A7183F241D9DQ38917152-33B0F9F4-076C-4AEB-98E6-564AD5FD63B9Q38939544-A0DB7C29-B8AB-45F4-9D85-1A155AE5C4B2Q39001919-5AFF27D5-1492-4169-9745-FFBEBCDB6DB5Q39245953-885E71DE-E92B-4A08-8688-14DF696CA8D8Q39606826-E14E79D2-A7D8-40FE-B4B1-F6787EC9E7A4Q40275251-F24C4045-908B-4731-9051-C0F4EDFA720CQ41948216-7E987BB4-D83F-44AF-A919-902EB794363CQ42379844-EF55B9A5-4A01-4F97-8CE1-CB1EBFDB3696Q46315743-99F1DF32-C865-4ECE-8A11-513AB0149BCFQ46774762-D12B78C4-2AE9-44C6-B952-CEF66F3CCD55Q50051086-8B408D64-21C4-464A-940B-F0AD657C4BC7Q51222204-95A2CDB4-4274-4C8C-8A7D-3A5494ED7B7DQ51730628-C1F6771E-89BD-4F58-90F5-AD51495156C0Q52676386-004D044D-B49A-4DE8-AF59-5DA7963D7F78Q55692383-B559F738-41B6-4D18-BC7D-AB7B99FA19BCQ57656314-434E36C6-5F79-4908-83C7-7B320844FF1DQ58842335-DBC89461-B370-460E-8A6E-63CCAF55C905
P2860
Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Nitro drugs for the treatment ...... present, and future prospects
@ast
Nitro drugs for the treatment ...... present, and future prospects
@en
Nitro drugs for the treatment ...... present, and future prospects
@nl
type
label
Nitro drugs for the treatment ...... present, and future prospects
@ast
Nitro drugs for the treatment ...... present, and future prospects
@en
Nitro drugs for the treatment ...... present, and future prospects
@nl
prefLabel
Nitro drugs for the treatment ...... present, and future prospects
@ast
Nitro drugs for the treatment ...... present, and future prospects
@en
Nitro drugs for the treatment ...... present, and future prospects
@nl
P2860
P3181
P356
P1476
Nitro drugs for the treatment ...... present, and future prospects
@en
P2093
Stephen Patterson
P2860
P304
P3181
P356
10.1016/J.PT.2014.04.003
P407
P50
P577
2014-06-01T00:00:00Z