Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases
about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesNucleotide excision repair in eukaryotesMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairConserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair EnzymesCellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active siteskNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activityImplementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.Comprehensive classification of the PIN domain-like superfamilyXRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.The wonders of flap endonucleases: structure, function, mechanism and regulation.Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7.Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.Structural studies of DNA end detection and resection in homologous recombination.DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction.Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substratesFlap endonuclease of bacteriophage T7: Possible roles in RNA primer removal, recombination and host DNA breakdown.Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.Observation of unpaired substrate DNA in the flap endonuclease-1 active site.Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage.Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleasesRegional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1
P2860
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P2860
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@ast
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@en
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@nl
type
label
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@ast
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@en
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@nl
prefLabel
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@ast
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@en
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@nl
P2093
P2860
P1476
Unpairing and gating: sequence ...... n by FEN superfamily nucleases
@en
P2093
Jane A Grasby
John M Atack
Susan E Tsutakawa
P2860
P356
10.1016/J.TIBS.2011.10.003
P407
P577
2011-11-24T00:00:00Z