A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
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The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendritesVAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasisCharacterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosisIdentification and functional analysis of a SLC33A1: c.339T>G (p.Ser113Arg) variant in the original SPG42 familySperm and oocyte communication mechanisms controlling C. elegans fertilityThe Presynaptic Microtubule Cytoskeleton in Physiological and Pathological Conditions: Lessons from Drosophila Fragile X Syndrome and Hereditary Spastic ParaplegiasInter-organelle ER-endolysosomal contact sites in metabolism and disease across evolutionGolgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport VesiclesThe Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from DrosophilaAutophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALSDisruption of axonal transport perturbs bone morphogenetic protein (BMP)--signaling and contributes to synaptic abnormalities in two neurodegenerative diseasesGrowth differentiation factor 6 as a putative risk factor in neuromuscular degenerationAmyotrophic lateral sclerosis-linked mutant VAPB inclusions do not interfere with protein degradation pathways or intracellular transport in a cultured cell modelDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseStructural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulationsA Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome.The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality controlInteractions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumModelling amyotrophic lateral sclerosis: progress and possibilitiesTransgenic Drosophila models of Alzheimer's disease and tauopathiesMSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?Drosophila melanogaster in the study of human neurodegeneration.Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis.Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway.Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophiesA genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis.Flightless flies: Drosophila models of neuromuscular disease.β-N-methylamino-L-alanine induces neurological deficits and shortened life span in DrosophilaDownregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.Network analyses reveal novel aspects of ALS pathogenesisA fruitful endeavor: modeling ALS in the fruit flySecreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria.A Presynaptic Regulatory System Acts Transsynaptically via Mon1 to Regulate Glutamate Receptor Levels in Drosophila.Vapb/Amyotrophic lateral sclerosis 8 knock-in mice display slowly progressive motor behavior defects accompanying ER stress and autophagic response.Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.Insights into ALS pathomechanisms: from flies to humans.Probing mechanisms that underlie human neurodegenerative diseases in Drosophila
P2860
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P2860
A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@ast
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@en
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@nl
type
label
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@ast
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@en
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@nl
prefLabel
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@ast
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@en
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@nl
P2093
P2860
P3181
P1433
P1476
A Drosophila model of ALS: hum ...... a dominant negative mechanism
@en
P2093
Anuradha Ratnaparkhi
Felix E Schweizer
George M Lawless
George R Jackson
Peyman Golshani
P2860
P3181
P356
10.1371/JOURNAL.PONE.0002334
P407
P577
2008-01-01T00:00:00Z