Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
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RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes.Identification of BECN1 and ATG14 Coiled-Coil Interface Residues That Are Important for Starvation-Induced AutophagyCharacterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complexIdentifying and Visualizing Macromolecular Flexibility in Structural BiologyThe diverse and expanding role of mass spectrometry in structural and molecular biologyA mutation in VPS15 (PIK3R4) causes a ciliopathy and affects IFT20 release from the cis-GolgiDiversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate.Nanobodies to Study G Protein-Coupled Receptor Structure and Function.BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated AutophagyDynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagyULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels.Architecture of the ATG2B-WDR45 complex and an aromatic Y/HF motif crucial for complex formation.Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis.Polyglutamine tracts regulate beclin 1-dependent autophagy.Insights into autophagosome biogenesis from in vitro reconstitutions.Conformational flexibility of BECN1: Essential to its key role in autophagy and beyond.Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity.Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry.Next-generation electron microscopy in autophagy research.Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics.Sensing Membrane Curvature in Macroautophagy.Mechanisms of Autophagy Initiation.The BECN1 N-terminal domain is intrinsically disordered.An autophagy-related kinase is essential for the symbiotic relationship between Phaseolus vulgaris and both rhizobia and arbuscular mycorrhizal fungi.Aspergillus niger Prolyl Endoprotease for Hydrogen-Deuterium Exchange Mass Spectrometry and Protein Structural Studies.Identifying intrinsically disordered protein regions likely to undergo binding-induced helical transitionsDetermination of VPS34/PIK3C3 Activity in vitro Utilising 32P-γATP.Structural transitions in conserved, ordered Beclin 1 domains essential to regulating autophagy.A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex.Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity.Arabidopsis VPS38 is required for vacuolar trafficking but dispensable for autophagy.Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation.
P2860
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P2860
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
description
2015 nî lūn-bûn
@nan
2015 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Structure and flexibility of t ...... s of its function on membranes
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Structure and flexibility of t ...... of its function on membranes.
@ast
Structure and flexibility of t ...... of its function on membranes.
@en
type
label
Structure and flexibility of t ...... s of its function on membranes
@nl
Structure and flexibility of t ...... of its function on membranes.
@ast
Structure and flexibility of t ...... of its function on membranes.
@en
prefLabel
Structure and flexibility of t ...... s of its function on membranes
@nl
Structure and flexibility of t ...... of its function on membranes.
@ast
Structure and flexibility of t ...... of its function on membranes.
@en
P2093
P2860
P50
P3181
P356
P1433
P1476
Structure and flexibility of t ...... of its function on membranes.
@en
P2093
Chris Johnson
Ksenia Rostislavleva
Lufei Zhang
Nicholas T Ktistakis
P2860
P304
P3181
P356
10.1126/SCIENCE.AAC7365
P407
P577
2015-10-01T00:00:00Z