The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp
about
A structure-based benchmark for protein-protein binding affinityCooperative binding of DNA and CBFbeta to the Runt domain of the CBFalpha studied via MD simulations.Structural analysis of the autoinhibition of Ets-1 and its role in protein partnershipsStructure of the sporulation-specific transcription factor Ndt80 bound to DNA.Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activitySignatures of Protein-DNA Recognition in Free DNA Binding SitesStructural basis of Ets1 activation by Runx1Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancerCharacterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBFβ and CRL5 E3 ubiquitin ligase componentsMutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitThe evolutionary origin of the Runx/CBFbeta transcription factors--studies of the most basal metazoansStructure and Biophysics of CBFβ/RUNX and Its Translocation Products.Overview of protein structural and functional folds.CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.Recurrent CDC25C mutations drive malignant transformation in FPD/AML.Core binding factor β (CBFβ) is retained in the midbody during cytokinesisDistinct contributions of conserved modules to Runt transcription factor activityCore-binding factor β increases the affinity between human Cullin 5 and HIV-1 Vif within an E3 ligase complexLeucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic developmentCBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genesStructure-based predictions broadly link transcription factor mutations to gene expression changes in cancers.Runx transcription factors repress human and murine c-Myc expression in a DNA-binding and C-terminally dependent manner.New mechanisms of AML1 gene alteration in hematological malignancies.Runx3 knockouts and stomach cancerRunx3 and Runx1 are required for CD8 T cell development during thymopoiesis.Vif determines the requirement for CBF-β in APOBEC3 degradationRUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells.RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingMechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11.Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healingMolecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1 on the TCRα gene enhancer.Host restriction factors in retroviral infection: promises in virus-host interaction.The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element.Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations.
P2860
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P2860
The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp
description
2001 nî lūn-bûn
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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2001 թվականի ապրիլին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
@zh-hant
2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@ast
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@en
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@nl
type
label
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@ast
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@en
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@nl
prefLabel
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@ast
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@en
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@nl
P2093
P3181
P356
P1476
The leukemia-associated AML1 ( ...... a DNA-induced molecular clamp
@en
P2093
P3181
P356
10.1038/86264
P577
2001-04-01T00:00:00Z