Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1) - Wikidata - awgldk - TriplyDB

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

http://www.wikidata.org/entity/Q27643224

about

Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -Secretase Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Conformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation Equilibria The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.It's all in the crystals…BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).Developing β-secretase inhibitors for treatment of Alzheimer's disease.Path-integral method for predicting relative binding affinities of protein-ligand complexes.beta-Secretase as a therapeutic target for Alzheimer's disease.Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors.Recent progress in the drug discovery of non-peptidic BACE1 inhibitors.Advances in the identification of β-secretase inhibitors.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.New directions for protease inhibitors directed drug discovery.From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease.Heterocycles in peptidomimetics and pseudopeptides: design and synthesis.Triazolyl tryptoline derivatives as β-secretase inhibitors.Population density analysis for determining the protonation state of the catalytic dyad in BACE1-tertiary carbinamine-based inhibitor complex.Structure-guided design of β-secretase (BACE-1) inhibitors.Ligand-free Cu(ii)-mediated aerobic oxidations of aldehyde hydrazones leading to N,N'-diacylhydrazines and 1,3,4-oxadiazoles.

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P2860

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

http://www.wikidata.org/entity/Q27643224

description

2006 nî lūn-bûn

@nan

2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

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name

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

@ast

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

@en

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

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type

label

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

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Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

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Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

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prefLabel

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

@ast

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

@en

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

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Journal of Medicinal Chemistry

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Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

@en

P2093

Adam J Simon

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Amy S Espeseth

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Beth Pietrak

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Daria J Hazuda

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Dennis Colussi

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Georgia B McGaughey

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Harold G Selnick

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Hemaka A Rajapakse

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Joseph P Vacca

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Katherine Tugusheva

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7270-3

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scholarly article

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88954

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10.1021/JM061046R

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25

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49

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2006-12-14T00:00:00Z

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17149856

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