Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
about
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interactionCalpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degenerationCalpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1BCysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsThe Structure and Interactions of SpoIISA and SpoIISB, a Toxin-Antitoxin System in Bacillus subtilisUnique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vectorCrystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-handCapn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinomaSkeletal muscle-specific calpain is an intracellular Na+-dependent proteaseMolecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpainUnderstanding the interaction determinants of CAPN1 inhibition by CAST4 from bovines using molecular modeling techniques.Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC.Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness.Homology modeling study of bovine μ-calpain inhibitor-binding domains.A New Insight into the Role of Calpains in Post-mortem Meat Tenderization in Domestic Animals: A review.Calpain cleavage prediction using multiple kernel learning.Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design.Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla.Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failureThe N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Interaction between calpain-1 and HSP90: new insights into the regulation of localization and activity of the protease.Nanomedicine strategies for treatment of secondary spinal cord injury.Neuroprotective strategies against calpain-mediated neurodegeneration.Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3.Calpain chronicle--an enzyme family under multidisciplinary characterizationVital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.Structural modeling of a novel CAPN5 mutation that causes uveitis and neovascular retinal detachmentTargeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetesIn silico affinity profiling of neuroactive polyphenols for post-traumatic calpain inactivation: a molecular docking and atomistic simulation sensitivity analysis.Calpains promote α2β1 integrin turnover in nonrecycling integrin pathwayIncreased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis.CAPN5 mutation in hereditary uveitis: the R243L mutation increases calpain catalytic activity and triggers intraocular inflammation in a mouse modelCalpastatin controls polymicrobial sepsis by limiting procoagulant microparticle releaseApicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.Regulation and physiological roles of the calpain system in muscular disordersCalcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like PeptidaseAffinity purification of human m-calpain through an intrinsically disordered inhibitor, calpastatin.Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancerDevelopment of α-helical calpain probes by mimicking a natural protein-protein interaction.
P2860
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P2860
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@ast
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@en
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@nl
type
label
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@ast
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@en
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@nl
prefLabel
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@ast
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@en
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@nl
P3181
P356
P1433
P1476
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
@en
P2093
Peter L Davies
Rachel A Hanna
P2860
P2888
P304
P3181
P356
10.1038/NATURE07451
P407
P577
2008-11-01T00:00:00Z
P6179
1048835646