Discovery of XL413, a potent and selective CDC7 inhibitor

Discovery of XL413, a potent and selective CDC7 inhibitor

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http://www.wikidata.org/entity/Q27678902
Crystal structure of human CDC7 kinase in complex with its activator DBF4A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage responseThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsDDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approachCDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Regulation and roles of Cdc7 kinase under replication stress.Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer.Dbf4: the whole is greater than the sum of its partsCdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpointCell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness.Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1.Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.BRD4 facilitates replication stress-induced DNA damage response.DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling
P2860

Discovery of XL413, a potent and selective CDC7 inhibitor

Item
http://www.wikidata.org/entity/Q27678902
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2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Discovery of XL413, a potent and selective CDC7 inhibitor
@ast
Discovery of XL413, a potent and selective CDC7 inhibitor
@en
Discovery of XL413, a potent and selective CDC7 inhibitor
@nl
type
label
Discovery of XL413, a potent and selective CDC7 inhibitor
@ast
Discovery of XL413, a potent and selective CDC7 inhibitor
@en
Discovery of XL413, a potent and selective CDC7 inhibitor
@nl
prefLabel
Discovery of XL413, a potent and selective CDC7 inhibitor
@ast
Discovery of XL413, a potent and selective CDC7 inhibitor
@en
Discovery of XL413, a potent and selective CDC7 inhibitor
@nl
P1433
P1476
P2093
P304
P31
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P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Discovery of XL413, a potent and selective CDC7 inhibitor
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2012.04.024
P407
P433
P478
P50
P577
P698