Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase
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The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activityIn vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatasePIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasisPIKfyve: Partners, significance, debates and paradoxesArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytesArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionalityLoss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnoverPhosphatidylinositol 3,5-bisphosphate: low abundance, high significanceCharcot-Marie-Tooth disease and intracellular trafficPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides in the mammalian endo-lysosomal networkPI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase functionSynthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast.p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane.Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3.Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphateSpatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recyclingPathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4JRegulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesisMutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4JThe ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in CellsrSac3, a novel Sac domain phosphoinositide phosphatase, promotes neurite outgrowth in PC12 cellsPI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosomeThe phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infectionMembrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast.Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathwaysRescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.The Sac domain-containing phosphoinositide phosphatases: structure, function, and diseaseAt the poles across kingdoms: phosphoinositides and polar tip growthPhosphoinositide phosphatases in cell biology and disease.Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functionsDistinct pathogenic processes between Fig4-deficient motor and sensory neurons.
P2860
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P2860
Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@ast
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@en
Vacuole size control: regulati ...... s(3,5)P2-specific phosphatase.
@nl
type
label
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@ast
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@en
Vacuole size control: regulati ...... s(3,5)P2-specific phosphatase.
@nl
prefLabel
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@ast
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@en
Vacuole size control: regulati ...... s(3,5)P2-specific phosphatase.
@nl
P2093
P2860
P356
P1476
Vacuole size control: regulati ...... ns(3,5)P2-specific phosphatase
@en
P2093
Deborah M Anderson
Scott D Emr
Simon A Rudge
P2860
P356
10.1091/MBC.E03-05-0297
P407
P577
2004-01-01T00:00:00Z