about
Structure and functionality in flavivirus NS-proteins: perspectives for drug designStructural bases for substrate recognition and activity in Meaban virus nucleoside-2′-O-methyltransferasePreliminary crystallographic characterization of an RNA helicase from Kunjin virusPreliminary characterization of (nucleoside-2′-O-)-methyltransferase crystals from Meaban and Yokose flavivirusesCrystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral ReplicationFerredoxin-NADP+ reductase from Plasmodium falciparum undergoes NADP+-dependent dimerization and inactivation: functional and crystallographic analysisCrystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 proteinStructure and biochemical analysis of Kokobera virus helicaseTargeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principlesRecognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in FlavivirusDesigning Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2Crystal structure of a methyltransferase from a no-known-vector FlavivirusStructural basis for bivalent Smac-mimetics recognition in the IAP protein familyRecognition of Smac-mimetic compounds by the BIR domain of cIAP1Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-MimeticStructure-based inhibition of Norovirus RNA-dependent RNA polymerasesStructural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compoundsNaphthalene-sulfonate inhibitors of human norovirus RNA-dependent RNA-polymerasePPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking basesNF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathwayTargeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitorHemoprotein time-resolved X-ray crystallography.Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and BortezomibIvermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.Ebolavirus and Marburgvirus: insight the Filoviridae family.Delivery of suramin as an antiviral agent through liposomal systems.Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy.Flaviviral helicase: insights into the mechanism of action of a motor protein.Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition.The activator of apoptosis Smac-DIABLO acts as a tetramer in solutionIdentification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles.Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.Gelsolin pathogenic Gly167Arg mutation promotes domain-swap dimerization of the protein.Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor.Role and inhibition of GLI1 protein in cancer.One hundred years of X-ray diffraction, 50 years of structural biologyHomo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I: Synthesis
P50
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P50
description
hulumtuese
@sq
researcher
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wetenschapper
@nl
հետազոտող
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name
Eloise Mastrangelo
@ast
Eloise Mastrangelo
@en
Eloise Mastrangelo
@es
Eloise Mastrangelo
@fr
Eloise Mastrangelo
@nl
Eloise Mastrangelo
@sl
type
label
Eloise Mastrangelo
@ast
Eloise Mastrangelo
@en
Eloise Mastrangelo
@es
Eloise Mastrangelo
@fr
Eloise Mastrangelo
@nl
Eloise Mastrangelo
@sl
prefLabel
Eloise Mastrangelo
@ast
Eloise Mastrangelo
@en
Eloise Mastrangelo
@es
Eloise Mastrangelo
@fr
Eloise Mastrangelo
@nl
Eloise Mastrangelo
@sl
P106
P1153
14066347900
P21
P31
P496
0000-0002-5968-8386
P569
2000-01-01T00:00:00Z