A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
about
Linkage between the mechanisms of thrombocytopenia and thrombopoiesisA Novel Structural Unit in the N-terminal Region of FilaminsT granules in human platelets function in TLR9 organization and signaling.Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation.Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies.New insights into the versatile roles of platelet FlnA.Does size matter in platelet production?Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists.Lessons in platelet production from inherited thrombocytopenias.Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.Progress in understanding the diagnosis and molecular genetics of macrothrombocytopenias.Molecular basis of inherited thrombocytopenias.Microtubule and cortical forces determine platelet size during vascular platelet production.Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin.The filamins: organizers of cell structure and functionPlatelets: versatile effector cells in hemostasis, inflammation, and the immune continuumArtificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing.FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and plateletsGPIbα regulates platelet size by controlling the subcellular localization of filaminMVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions.Complex roles of filamin-A mediated cytoskeleton network in cancer progression.Platelets: Context-Dependent Vascular Protectors or Mediators of Disease.RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic fibrosis transmembrane conductance regulator.The PAK system links Rho GTPase signaling to thrombin-mediated platelet activationPlatelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemiap21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear.The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation.Filamin-a-related myxomatous mitral valve dystrophy: genetic, echocardiographic and functional aspects.Novel platelet activation receptor CLEC-2: from discovery to prospects.Advances in our understanding of the molecular basis of disorders of platelet function.The effects of arterial flow on platelet activation, thrombus growth, and stabilization.Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2.Platelets in inflammation and immunity.Of von Willebrand factor and platelets.Systems biology of platelet-vessel wall interactions.New Concepts and Mechanisms of Platelet Activation Signaling.DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling
P2860
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P2860
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
description
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im August 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/08/30)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/08/30)
@nl
наукова стаття, опублікована в серпні 2010
@uk
مقالة علمية (نشرت في 30-8-2010)
@ar
name
A novel interaction between Fl ...... eceptor signaling and function
@ast
A novel interaction between Fl ...... eceptor signaling and function
@en
A novel interaction between Fl ...... eceptor signaling and function
@nl
type
label
A novel interaction between Fl ...... eceptor signaling and function
@ast
A novel interaction between Fl ...... eceptor signaling and function
@en
A novel interaction between Fl ...... eceptor signaling and function
@nl
prefLabel
A novel interaction between Fl ...... eceptor signaling and function
@ast
A novel interaction between Fl ...... eceptor signaling and function
@en
A novel interaction between Fl ...... eceptor signaling and function
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
A novel interaction between Fl ...... eceptor signaling and function
@en
P2093
Antonija Jurak Begonja
Daniel Duerschmied
Denisa D Wagner
John H Hartwig
Sarah E Weber
P2860
P304
P3181
P356
10.1084/JEM.20100222
P407
P577
2010-08-16T00:00:00Z