Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis
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Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosisEvidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora BThe Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cellsProteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate.Kinetochore-microtubule interactions: steps towards bi-orientationLinking kinetochore-microtubule binding to the spindle checkpointThe small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpointExploring the functional interactions between Aurora B, INCENP, and survivin in mitosisEvolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugsThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingCell division: control of the chromosomal passenger complex in time and spaceThe current view for the silencing of the spindle assembly checkpointKinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivoThe chromosomal passenger complex and a mitotic kinesin interact with the Tousled-like kinase in trypanosomes to regulate mitosis and cytokinesisMolecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochoresAurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cellsSurvivin enhances Aurora-B kinase activity and localizes Aurora-B in human cellsIn-silico modeling of the mitotic spindle assembly checkpointAurora-A kinase is essential for bipolar spindle formation and early developmentTranscriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointThe cellular geography of aurora kinasesMidbody localization of Vinexin recruits Rhotekin to facilitate cytokinetic abscission.A Centromere-Signaling Network Underlies the Coordination among Mitotic EventsConnecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeresCell division: righting the check.A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitorPhosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly.Kinetochore localization of spindle checkpoint proteins: who controls whom?A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular functionCyclin B destruction triggers changes in kinetochore behavior essential for successful anaphaseAurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice.Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis.
P2860
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P2860
Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis
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2002 nî lūn-bûn
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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
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2002年论文
@wuu
name
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@ast
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@en
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@nl
type
label
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@ast
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@en
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@nl
prefLabel
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@ast
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@en
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@nl
P50
P3181
P1433
P1476
Inhibition of aurora B kinase ...... icrotubule dynamics in mitosis
@en
P2093
Mark L McCleland
P3181
P356
10.1016/S0960-9822(02)00887-4
P407
P577
2002-06-04T00:00:00Z