The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
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Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastasesFurin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse modelA truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3.Processing of proaugurin is required to suppress proliferation of tumor cell lines.Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cellsOvarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat.Lymphangiogenesis and lymphatic metastasis in breast cancer.Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasisVascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancerProSAAS-derived peptides are differentially processed and sorted in mouse brain and AtT-20 cellsRepression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases.Identification of proprotein convertase substrates using genome-wide expression correlation analysis.Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity.When it comes to blocking lymphatics, it is all a question of timeStructural basis for VEGF-C binding to neuropilin-2 and sequestration by a soluble splice form.Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomasIdentification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.The role of angiogenic factors in endometrial cancer.Transgenic overexpression of the proprotein convertase furin enhances skin tumor growthThe Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.Loss of endothelial furin leads to cardiac malformation and early postnatal death.Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway.Targeting lymphangiogenesis to prevent tumour metastasisA small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells.The proprotein convertase furin is required for trophoblast syncytializationE-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-β in the bone microenvironmentPlasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Elevated in Patients With Peripheral Artery Disease and Associated With Metabolic Disorders and Dysfunction in Circulating Progenitor Cells.Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.The non-canonical role of vascular endothelial growth factor-C axis in cancer progressionCirculating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a).Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D.T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
P2860
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P2860
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@ast
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@en
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@nl
type
label
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@ast
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@en
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@nl
prefLabel
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@ast
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@en
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@nl
P2093
P2860
P3181
P356
P1476
The secretory proprotein conve ...... VEGF-C to induce tumorigenesis
@en
P2093
Abdel-Majid Khatib
Ajoy Basak
Geraldine Siegfried
Jadwiga Marcinkiewicz
James A Cromlish
Michel Chrétien
Nabil G Seidah
Suzanne Benjannet
P2860
P304
P3181
P356
10.1172/JCI17220
P407
P577
2003-06-01T00:00:00Z