High susceptibility to fatty liver disease in two-pore channel 2-deficient mice - Wikidata - awgldk - TriplyDB

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

http://www.wikidata.org/entity/Q28246421

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Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.Regulation of lysosomal ion homeostasis by channels and transporters Two-pore channels at the intersection of endolysosomal membrane traffic Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart Two-Pore Channels and Parkinson's Disease: Where's the Link?Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis.Lysosomal physiology.Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.Function and dysfunction of two-pore channels.Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.Two-Pore Channels: Lessons from Mutant Mouse Models Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.Lessons from hepatocyte-specific Cyp51 knockout mice: impaired cholesterol synthesis leads to oval cell-driven liver injury.Vacuolar ATPase in phagosome-lysosome fusion.Organellar channels and transporters.Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.TPC2 controls pigmentation by regulating melanosome pH and size Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.Poring over two-pore channel pore mutants.The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.Mechanisms of Filovirus Entry.Tuning the ion selectivity of two-pore channels.Departure gate of acidic Ca²⁺ confirmed.Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling.Connecting Ca2+ and lysosomes to Parkinson disease.Deviant lysosomal Ca2+ signalling in neurodegeneration. An introduction.Isolated pores dissected from human two-pore channel 2 are functional.Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.Lysosomal Calcium in Neurodegeneration.NAADP-evoked Ca2+ signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.

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High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

http://www.wikidata.org/entity/Q28246421

description

2014 nî lūn-bûn

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2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@ast

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@en

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@nl

type

label

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@ast

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@en

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@nl

prefLabel

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@ast

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@en

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@nl

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Nature Communications

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High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

@en

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Albert Haas

http://www.w3.org/2001/XMLSchema#string

Bernd Schröder

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Cheng-Chang Chen

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Christian A Luber

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Christian Wahl-Schott

http://www.w3.org/2001/XMLSchema#string

Christina Fendel

http://www.w3.org/2001/XMLSchema#string

Christoph Müller

http://www.w3.org/2001/XMLSchema#string

Daniel Teupser

http://www.w3.org/2001/XMLSchema#string

Elisabeth Butz

http://www.w3.org/2001/XMLSchema#string

Franz Bracher

http://www.w3.org/2001/XMLSchema#string

P2860

Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

NAADP mobilizes calcium from acidic organelles through two-pore channels

Two-pore channels form homo- and heterodimers

Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Bile acid transporters: structure, function, regulation and pathophysiological implications

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

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4699

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scholarly article

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4502320

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10.1038/NCOMMS5699

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5

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Oliver Griesbeck

Bernd H Northoff

Christian Grimm

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2014-08-21T00:00:00Z

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264991632

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1022149333

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25144390

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