about
Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase IBiochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesRif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replicationPhosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityNovel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexesCleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme AOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKReplication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cellsProteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cellsDrugging topoisomerases: lessons and challenges8-Oxoguanine rearranges the active site of human topoisomerase IStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexCrystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitorCellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocketActivities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 IntegraseStructural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapyStructural basis for recognition of 5′-phosphotyrosine adducts by Tdp2Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 InhibitorsRepair of and checkpoint response to topoisomerase I-mediated DNA damageTopoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sitesRelative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell linesDNA topoisomerases and their poisoning by anticancer and antibacterial drugsEcteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cellsCollaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repairExploring DNA topoisomerase I ligand space in search of novel anticancer agentsIdentification of a predominant co-regulation among kinetochore genes, prospective regulatory elements, and association with genomic instabilityBinding of an Indenoisoquinoline to the topoisomerase-DNA complex induces reduction of linker mobility and strengthening of protein-DNA interactionSolvent dependency of the UV-Vis spectrum of indenoisoquinolines: role of keto-oxygens as polarity interaction probesGene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotypeNCI-60 whole exome sequencing and pharmacological CellMiner analysesHigh resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMinerTargeting chk2 kinase: molecular interaction maps and therapeutic rationaleTranscription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cellsGenome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisonsExon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intronThe structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Yves Pommier
@ast
Yves Pommier
@en
Yves Pommier
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Yves Pommier
@nl
Yves Pommier
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type
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Yves Pommier
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Yves Pommier
@en
Yves Pommier
@es
Yves Pommier
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Yves Pommier
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prefLabel
Yves Pommier
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Yves Pommier
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Yves Pommier
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Yves Pommier
@nl
Yves Pommier
@sl