Multi-target drugs: the trend of drug research and development - Wikidata - awgldk - TriplyDB

Multi-target drugs: the trend of drug research and development

Multi-target drugs: the trend of drug research and development

http://www.wikidata.org/entity/Q28480888

about

Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Heterogeneity of glycolysis in cancers and therapeutic opportunities.Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery A ranking method for the concurrent learning of compounds with various activity profiles.Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs Prediction of the P. falciparum target space relevant to malaria drug discovery Is the United States still dominant in the global pharmaceutical innovation network?Substrate-driven mapping of the degradome by comparison of sequence logos Determining the Degree of Promiscuity of Extensively Assayed Compounds A Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract.Integrative analysis for identifying joint modular patterns of gene-expression and drug-response data.Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.Integrating systems biology sources illuminates drug action.Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.Systematic synergy modeling: understanding drug synergy from a systems biology perspective.Low potency toxins reveal dense interaction networks in metabolism.A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain.Novel Aurora/vascular endothelial growth factor receptor dual kinase inhibitor as treatment for hepatocellular carcinoma.An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes Unravelling druggable signalling networks that control F508del-CFTR proteostasis Organometallic Iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis.A survey of chinese medicinal herbal treatment for chemotherapy-induced oral mucositis.Acupuncture and herbal medicine for cancer patients.A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula.CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology.Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).Analysis of Pogostemon cablin from pharmaceutical research to market performances.Multi-target drugs to address multiple checkpoints in complex inflammatory pathologies: evolutionary cues for novel "first-in-class" anti-inflammatory drug candidates: a reviewer's perspective.Use of machine learning approaches for novel drug discovery.A CD13-targeting peptide integrated protein inhibits human liver cancer growth by killing cancer stem cells and suppressing angiogenesis.Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth.Analyzing compound activity records and promiscuity degrees in light of publication statistics.Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis

P2860

Q26745421-2C422671-FC3C-4639-8696-4A21021DA8CF Q27008867-82BBC53A-3408-49CC-BE56-53BA37CB9D89 Q27693375-D0D40D9D-14D0-418D-975C-1F856396D842 Q27702294-B4C3EDB5-853D-4C47-9BE3-79DE9B08FF56 Q27902271-2C15AD7A-A20D-4A57-8525-0D121A43B184 Q28074736-241A69E0-75F6-46CE-BA3F-F3E44B828991 Q28534474-8A60B6CA-6BC3-4315-890B-E02C0640009D Q28534835-A01118D3-C832-42BA-B6D1-65CD1CA07758 Q28535104-D83A3B0A-B8E6-4766-8CA7-B2F90D793BBB Q28551408-DCC01E0D-65FD-4F9B-A074-A40D646CAEF9 Q28554086-5C5A3FEA-83B1-4C62-AFA7-CDAF5C18CE5A Q30352305-3317D798-AA0F-41AB-97DB-F71A1B227FB6 Q31041986-3FC77904-B271-4403-96E1-A57EEB8C2BA7 Q33579016-02A4389B-01B2-42D9-81DD-5E46B9D37D9D Q33645618-98A18B7B-EF03-4986-8291-B1F5EA8DAC36 Q34656871-64C0C8B8-5C3F-41AC-9325-592BCA9994A5 Q35203658-1E59F3F0-3373-4EEE-A609-8B39C9F01A9F Q35777950-8C1222E1-3274-4474-841B-E4F7FE33F8D4 Q35929358-780F11E5-8E8D-478A-859C-9BE43A2A9433 Q36011829-87692D2A-4E0A-4AFD-B2EC-9170986E6633 Q36016223-C40BA9A9-B59E-44F4-8804-57481A5C9D7F Q36336086-769597B3-AFC3-4900-BE03-09651D9B2DEE Q36568529-81420528-09C7-4D9F-97D7-918394DB4D7F Q36952837-3ECABD84-C3FF-432A-96C4-549D86EB311F Q37316294-0FB1F300-1CFD-48D8-87AA-2A15888C43EC Q37382457-6CB26591-CB56-467B-B89F-027EB31553D2 Q37385774-B05AA8CE-225A-4B29-B133-82EE04201ACA Q37426159-5966A596-7722-4B78-99FB-224080B611D7 Q37736362-4192C546-F274-4E45-8EFD-11D78B242F38 Q38068529-E2A8EC81-9190-49D9-9E35-00BA3694CC38 Q38549528-BF58F18B-6343-4782-8AAD-88D84F7A4510 Q38712793-7DAB2315-309F-43C9-B60B-70CA5B7CEDD9 Q38725514-145761B4-7A39-4C6C-8245-80740BC5F120 Q38762468-0B05F48D-C340-4F70-80E0-22F69539CF0D Q38862724-96D95612-5A3A-4CB0-B178-FBFEF6932245 Q38999290-CCBA663C-0893-4DD9-AA70-FE70538F73B0 Q39064824-2B36BE2E-3E34-4299-8F22-5E68F3FAECE9 Q39652848-1C620FCE-90E6-41F9-A5C4-8BEDC58E9171 Q39787316-55957A1A-C72F-45A9-B40E-8BCD1C7BFD7F Q41531870-FCE8E8E5-0F64-4E60-988E-A71D23BC597D

P2860

Multi-target drugs: the trend of drug research and development

http://www.wikidata.org/entity/Q28480888

description

2012 nî lūn-bûn

@nan

2012 թուականին հրատարակուած գիտական յօդուած

@hyw

2012 թվականին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

Multi-target drugs: the trend of drug research and development

@ast

Multi-target drugs: the trend of drug research and development

@en

Multi-target drugs: the trend of drug research and development

@nl

type

label

Multi-target drugs: the trend of drug research and development

@ast

Multi-target drugs: the trend of drug research and development

@en

Multi-target drugs: the trend of drug research and development

@nl

prefLabel

Multi-target drugs: the trend of drug research and development

@ast

Multi-target drugs: the trend of drug research and development

@en

Multi-target drugs: the trend of drug research and development

@nl

P1433

Q28480888-0F6DFDE1-2DEC-4CFC-B2D0-AEB60C7A7AC6

P1476

Q28480888-C312D2E9-0E3C-4FDD-9B50-93B67A6FDB6C

P2093

Q28480888-33C365AD-5D63-43FA-9B8C-6D71EB6D9213

Q28480888-352FA012-C474-4523-A9CD-60E9F3F81E0D

Q28480888-B5B1EF7B-AC1C-48C8-A2A8-AD6DA6F24C29

P2860

Q28480888-05E73C74-15D2-473F-8983-18F1F0AFC311

Q28480888-08047152-0921-4535-852F-9F1637804BD5

Q28480888-0E00B3B8-A0EF-4E8D-A5DB-5D2B5434007B

Q28480888-15117C91-6FEA-4C51-BBFF-07964549E74C

Q28480888-22E5AFE9-67D1-4E04-9AFF-EA0A1BC9FDD7

Q28480888-4CB7C1C0-57A0-4E88-AF12-160B2334A223

Q28480888-4D8BBAC6-8D89-49AD-88AA-C706535240D9

Q28480888-612B6A97-3A38-4AD3-BB4F-F4E54FF05CBA

Q28480888-6390CD5F-B1F3-41A8-9121-AEA97CD9EAC3

Q28480888-66AEF519-1BF9-451D-AAF2-F473725452EE

P304

Q28480888-5B5365B5-B48D-4511-92A4-E95CA2538B9A

P31

Q28480888-2FA3BF4D-070F-4F31-AA43-8CCE53B3A491

P3181

Q28480888-09E9B998-A459-42D5-BBA6-1BF2F0947D06

P356

Q28480888-A021868A-0122-4836-AB07-9BB752EE996D

P407

Q28480888-4E23F63E-3F53-4F9A-9722-078F24F4041D

P433

Q28480888-110C5079-64B9-43E1-A68D-CEA5B071206E

P478

Q28480888-47F1CA43-6E1B-4F12-8ACA-F8790CC5F023

P50

Q28480888-93ED2B3B-3E60-43D8-BFBA-F2A18F0CAC43

P577

Q28480888-CAC07867-614A-44C5-9B6A-85473F90313F

P5875

Q28480888-557DD861-4CDA-4AA0-99BD-112FFAA43C09

P698

Q28480888-8B3A5523-70E5-43A6-B7EB-666A8F76B01D

P932

Q28480888-A25D5F34-6FBF-4F15-B11F-21A22AA1E968

P3181

P356

JOURNAL.PONE.0040262

P1433

P1476

Multi-target drugs: the trend of drug research and development

@en

P2093

Wei Pan

http://www.w3.org/2001/XMLSchema#string

Yi-Tao Wang

http://www.w3.org/2001/XMLSchema#string

Yuan-Jia Hu

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

The PI3K pathway as drug target in human cancer

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

Targeting EGFR in non-small-cell lung cancer: lessons, experiences, strategies

Drug discovery: playing dirty

Drug-target network

Utility of atherosclerosis imaging in the evaluation of high-density lipoprotein-raising therapies.

Natural products in drug discovery.

Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.

Multitargeting by curcumin as revealed by molecular interaction studies

P304

e40262

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

889195

http://www.w3.org/2001/XMLSchema#string

P356

10.1371/JOURNAL.PONE.0040262

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P50

P577

2012-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

228331859

http://www.w3.org/2001/XMLSchema#string

P698

22768266

http://www.w3.org/2001/XMLSchema#string

P932

3386979

http://www.w3.org/2001/XMLSchema#string