Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
about
The notch ligand JAGGED1 as a target for anti-tumor therapyThree-dimensional analysis of vascular development in the mouse embryoDevelopmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signallingBotch promotes neurogenesis by antagonizing NotchCerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sproutingAnimal Models in Studying Cerebral Arteriovenous MalformationContext-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations.Pulling on my heartstrings: mechanotransduction in cardiac development and functionA novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processingEndothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle developmentRBPJ mutations identified in two families affected by Adams-Oliver syndromeBiodistribution and toxicity of pegylated single wall carbon nanotubes in pregnant mice.Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potentialNotch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse developmentArtery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesisDosage-dependent requirement for mouse Vezf1 in vascular system developmentContext-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In VivoVascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesisEssential role of endothelial Notch1 in angiogenesisDll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cellsMind bomb-2 is an E3 ligase for Notch ligandAn allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular developmentThe PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular developmentThe Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expressionConditionals by inversion provide a universal method for the generation of conditional allelesENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation developmentMultiscale models of angiogenesisEndothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.Elongation, proliferation & migration differentiate endothelial cell phenotypes and determine capillary sproutingConstitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants.Sox17 is indispensable for acquisition and maintenance of arterial identityDistinct Notch signaling outputs pattern the developing arterial system.Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice.An obligatory role of mind bomb-1 in notch signaling of mammalian developmentFoxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli.KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia
P2860
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P2860
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
description
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Oktober 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/10/15)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/10/15)
@nl
наукова стаття, опублікована в жовтні 2004
@uk
مقالة علمية (نشرت في 15-10-2004)
@ar
name
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@ast
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@en
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@nl
type
label
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@ast
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@en
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@nl
prefLabel
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@ast
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@en
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@nl
P2093
P2860
P921
P356
P1433
P1476
Haploinsufficient lethality an ...... tions in Notch pathway mutants
@en
P2093
John R. Shutter
Kenji Tanigaki
Kevin L. Stark
Luke T. Krebs
Thomas Gridley
P2860
P304
P356
10.1101/GAD.1239204
P50
P577
2004-10-15T00:00:00Z