USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
about
DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsRole of Deubiquitinating Enzymes in DNA RepairFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workDeubiquitinating enzymes in cellular signaling and disease regulationUbiquitin-dependent regulation of Foxp3 and Treg functionUbiquitylation, neddylation and the DNA damage responseThe bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stabilityUSP9X regulates centrosome duplication and promotes breast carcinogenesis.Prognostic significance of TCF21 mRNA expression in patients with lung adenocarcinoma.High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancerUsp7 protects genomic stability by regulating Bub3.USP33, a new player in lung cancer, mediates Slit-Robo signaling.Centrosome dynamics as a source of chromosomal instabilityScreening of DUB activity and specificity by MALDI-TOF mass spectrometryCyclin B2 and p53 control proper timing of centrosome separationMitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer.Centrosomes are multifunctional regulators of genome stabilityNuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy.UCHL1 is a biomarker of aggressive multiple myeloma required for disease progressionAneuploidy in health, disease, and aging.The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exitA novel role for the deubiquitinase USP1 in the control of centrosome duplication.The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention.Deubiquitylating enzymes and DNA damage response pathways.Deubiquitylases from genes to organism.Centrosomes in spindle organization and chromosome segregation: a mechanistic view.Ubiquitin, the centrosome, and chromosome segregation.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.The X-linked deubiquitinase USP9X is an integral component of centrosome.USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.Aneuploidy in Cancer and Aging.The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.Regulation of the cell cycle and centrosome biology by deubiquitylases.Screening feature genes of lung carcinoma with DNA microarray analysis.Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.Molecular profiling identifies prognostic markers of stage IA lung adenocarcinoma.
P2860
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P2860
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
description
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
@ast
im Dezember 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/12/01)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/12/01)
@nl
наукова стаття, опублікована в грудні 2012
@uk
مقالة علمية (نشرت في ديسمبر 2012)
@ar
name
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@ast
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@en
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@nl
type
label
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@ast
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@en
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@nl
prefLabel
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@ast
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@en
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@nl
P2093
P2860
P3181
P356
P1476
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
@en
P2093
Dennis A. Wigle
Farhad Kosari
George Vasmatzis
Jan van Deursen
Jeffrey L. Salisbury
Oded Foreman
Paul J. Galardy
Ying Zhang
P2860
P304
P3181
P356
10.1172/JCI63084
P407
P577
2012-12-01T00:00:00Z