Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice
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G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heartImpaired activation of murine platelets lacking G alpha(i2)Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivityMultiple neurological abnormalities in mice deficient in the G protein GoLack of muscarinic regulation of Ca(2+) channels in G(i2)alpha gene knockout mouse heartsMost central nervous system D2 dopamine receptors are coupled to their effectors by GoGalphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation.Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat.Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.Vagal control of myocardial contractility in humans.Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists.The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.Absence of the inhibitory G-protein Galphai2 predisposes to ventricular cardiac arrhythmia.Targeted inactivation of alphai2 or alphai3 disrupts activation of the cardiac muscarinic K+ channel, IK+Ach, in intact cells.Juxtaglomerular cell CaSR stimulation decreases renin release via activation of the PLC/IP(3) pathway and the ryanodine receptor.Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation.Identification of bdm-1, a gene involved in G protein beta-subunit function and alpha-subunit accumulation.Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atriumThe Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias.Regulation, Signaling, and Physiological Functions of G-Proteins.G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes.Enhanced bradykinin-stimulated phospholipase C activity in murine embryonic stem cells lacking the G-protein alphaq-subunit.Disruption of cytoskeletal integrity impairs Gi-mediated signaling due to displacement of Gi proteins.Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene.Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts.Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.Coordinate expression of the alpha and beta subunits of heterotrimeric G proteins involves regulation of protein degradation in CHO cells.Effect of deletion of the major brain G-protein alpha subunit (alpha(o)) on coordination of G-protein subunits and on adenylyl cyclase activity.G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes.
P2860
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P2860
Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice
description
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1996
@ast
im April 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/04/16)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/04/16)
@nl
наукова стаття, опублікована у квітні 1996
@uk
name
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@ast
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@en
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@nl
type
label
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@ast
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@en
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@nl
prefLabel
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@ast
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@en
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@nl
P2093
P2860
P356
P1476
Adenylyl cyclase inhibition an ...... nd cells from Gi2 alpha-/-mice
@en
P2093
K. Spicher
L. Birnbaumer
U. Rudolph
P2860
P304
P356
10.1073/PNAS.93.8.3209
P407
P577
1996-04-16T00:00:00Z