Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth
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Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neuronsNeuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability.Presynaptic Molecular Determinants of Quantal SizeVGLUTs and Glutamate Synthesis-Focus on DRG Neurons and PainGlucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cellsGlutamate Release.Modeling resilience to schizophrenia in genetically modified mice: a novel approach to drug discovery.Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.A local glutamate-glutamine cycle sustains synaptic excitatory transmitter releaseFast homeostatic plasticity of inhibition via activity-dependent vesicular fillingGlutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation.Glutaminase 1 is essential for the differentiation, proliferation, and survival of human neural progenitor cells.Network of brain protein level changes in glutaminase deficient fetal miceTargeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminaseGlutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibitionGenetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice.Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation.Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.Loss of function mutation in glutamic pyruvate transaminase 2 (GPT2) causes developmental encephalopathyNeural control of breathing: insights from genetic mouse models.In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage.Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brainBrain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout miceHow high-resolution basal-state functional imaging can guide the development of new pharmacotherapies for schizophrenia.Glutamate pharmacology and metabolism in peripheral primary afferents: physiological and pathophysiological mechanisms.Vesicular and plasma membrane transporters for neurotransmitters.Therapeutic strategies impacting cancer cell glutamine metabolism.Maintaining the presynaptic glutamate supply for excitatory neurotransmission.Brain glutaminases.Glutamine fuels proliferation but not migration of endothelial cells.Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy.Wnt signaling and cellular metabolism in osteoblasts.Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)Dopamine neuron dependent behaviorsmediated by glutamate cotransmission.Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease.Good housekeeping.Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter.Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
P2860
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P2860
Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth
description
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im April 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/04/26)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/04/26)
@nl
наукова стаття, опублікована у квітні 2006
@uk
مقالة علمية نشرت في 26-4-2006 حول موضوع: دماغ
@ar
name
Mice lacking brain/kidney phos ...... or and die shortly after birth
@ast
Mice lacking brain/kidney phos ...... or and die shortly after birth
@en
Mice lacking brain/kidney phos ...... or and die shortly after birth
@nl
type
label
Mice lacking brain/kidney phos ...... or and die shortly after birth
@ast
Mice lacking brain/kidney phos ...... or and die shortly after birth
@en
Mice lacking brain/kidney phos ...... or and die shortly after birth
@nl
prefLabel
Mice lacking brain/kidney phos ...... or and die shortly after birth
@ast
Mice lacking brain/kidney phos ...... or and die shortly after birth
@en
Mice lacking brain/kidney phos ...... or and die shortly after birth
@nl
P2093
P2860
P50
P921
P1476
Mice lacking brain/kidney phos ...... or and die shortly after birth
@en
P2093
Agnès Conjard
Arthur S Foutz
Gretchen M Miller
Jonathan Polan
Michel Hamon
Muriel Thoby-Brisson
Renée Jorisch
Sandrine Parrot
P2860
P304
P356
10.1523/JNEUROSCI.4241-05.2006
P407
P577
2006-04-01T00:00:00Z