Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
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Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitorsNf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrowMouse models of neurofibromatosis 1 and 2.A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressorThe haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complexInsights into the pathogenesis of neurofibromatosis 1 vasculopathyLoss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cellsNeurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytesHyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functionsHyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitroMolecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsSurvey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesionsGenetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity.Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.Mast cells and the neurofibroma microenvironmentNF1 inactivation in adult acute myelogenous leukemiaIncreased noise as an effect of haploinsufficiency of the tumor-suppressor gene neurofibromatosis type 1 in vitro.Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.Neurofibromas in NF1: Schwann cell origin and role of tumor environmentGenetic interactions between neurofibromin and endothelin receptor B in miceCardiovascular disease in neurofibromatosis 1: report of the NF1 Cardiovascular Task Force.Neurofibromatosis 1: clinical manifestations and diagnostic criteria.Antiangiogenesis in neurofibromatosis 1.Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferationMolecular dissection of isolated disease features in mosaic neurofibromatosis type 1.Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors: II. The role of dysregulated growth factor signaling.Quantitative effects of Nf1 inactivation on in vivo hematopoiesisPartial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric.Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cellsHeterozygous inactivation of the Nf1 gene in myeloid cells enhances neointima formation via a rosuvastatin-sensitive cellular pathwayThe Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas.Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression.Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells
P2860
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P2860
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
description
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2000
@ast
im Januar 2000 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2000/01/03)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/01/03)
@nl
наукова стаття, опублікована в січні 2000
@uk
مقالة علمية (نشرت في 3-1-2000)
@ar
name
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@ast
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@en
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@nl
type
label
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@ast
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@en
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@nl
prefLabel
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@ast
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@en
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@nl
P2093
P2860
P921
P356
P1476
Genetic and biochemical eviden ...... te and mast cell fates in vivo
@en
P2093
D A Ingram
D A Williams
M J Wenning
P2860
P304
P356
10.1084/JEM.191.1.181
P407
P577
2000-01-01T00:00:00Z