PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome - Wikidata - awgldk - TriplyDB

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

http://www.wikidata.org/entity/Q29543488

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mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state Autophagy in lysosomal storage disorders In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.Transient receptor potential (TRP) channels and cardiac fibrosis Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease The role of TRPMLs in endolysosomal trafficking and function Endosome maturation Phosphoinositides: tiny lipids with giant impact on cell regulation Lysosomal membrane proteins and their central role in physiology Phosphoinositides in the mammalian endo-lysosomal network The Amyloid Precursor Protein Controls PIKfyve Function Mucolipin co-deficiency causes accelerated endolysosomal vacuolation of enterocytes and failure-to-thrive from birth to weaning The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death Molecular Bases of Multimodal Regulation of a Fungal Transient Receptor Potential (TRP) Channel Phosphatidic Acid Sequesters Sec18p from cis-SNARE Complexes to Inhibit Priming Targeting TRPM2 in ROS-Coupled Diseases Regulation of lysosomal ion homeostasis by channels and transporters A lysosome-centered view of nutrient homeostasis Above the fray: Surface remodeling by secreted lysosomal enzymes leads to endocytosis-mediated plasma membrane repair Two-pore channels at the intersection of endolysosomal membrane traffic A lipid switch unlocks Parkinson's disease-associated ATP13A2 Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes Two-pore channels (TPCs): current controversies Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J Identification and analysis of cation channel homologues in human pathogenic fungi The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.Lysosomal exocytosis and lipid storage disorders.AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve

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P2860

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

http://www.wikidata.org/entity/Q29543488

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

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name

PI(3,5)P2 controls membrane tr ...... e channels in the endolysosome

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Nature Communications

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PI(3,5)P2 controls membrane tr ...... e channels in the endolysosome

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Dongbiao Shen

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Haoxing Xu

http://www.w3.org/2001/XMLSchema#string

Lois S. Weisman

http://www.w3.org/2001/XMLSchema#string

Markus Delling

http://www.w3.org/2001/XMLSchema#string

Qi Zhang

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Taylor Dawson

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Xian-ping Dong

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Xiang Wang

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Xinran Li

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Xiping Cheng

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P2860

Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel

NAADP mobilizes calcium from acidic organelles through two-pore channels

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase

Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase

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1-11

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349400

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10.1038/NCOMMS1037

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4

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1

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20802798

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2928581

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