Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations
about
Full-length prion protein aggregates to amyloid fibrils and spherical particles by distinct pathways.Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP.Molecular dynamics simulations capture the misfolding of the bovine prion protein at acidic pHDynamic diagnosis of familial prion diseases supports the β2-α2 loop as a universal interference target.Modeling amyloid-beta as homogeneous dodecamers and in complex with cellular prion protein.Prion protein misfolding.NMR structure and CD titration with metal cations of human prion alpha2-helix-related peptides.Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein.Searching for factors that distinguish disease-prone and disease-resistant prions via sequence analysisDifferential stability of the bovine prion protein upon urea unfoldingElectrostatics of proteins in dielectric solvent continua. II. First applications in molecular dynamics simulations.Emulating structural stability of Pseudomonas mendocina lipase: in silico mutagenesis and molecular dynamics studies.
P2860
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P2860
Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations
description
2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
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name
Structural instability of the ...... molecular dynamics simulations
@ast
Structural instability of the ...... molecular dynamics simulations
@en
type
label
Structural instability of the ...... molecular dynamics simulations
@ast
Structural instability of the ...... molecular dynamics simulations
@en
prefLabel
Structural instability of the ...... molecular dynamics simulations
@ast
Structural instability of the ...... molecular dynamics simulations
@en
P2093
P2860
P1433
P1476
Structural instability of the ...... molecular dynamics simulations
@en
P2093
Bernhard Schropp
Martina Stork
Paul Tavan
Thomas Hirschberger
P2860
P304
P356
10.1529/BIOPHYSJ.105.075341
P407
P577
2006-03-02T00:00:00Z