Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. - Wikidata - awgldk - TriplyDB

Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.

Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.

http://www.wikidata.org/entity/Q30480364

about

Basic mechanisms for recognition and transport of synaptic cargos Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity Multiple Roles of the Small GTPase Rab7 Functions of Rab Proteins at Presynaptic Sites Charcot-Marie-Tooth disease and intracellular traffic A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease.Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin Novel variant of neuronal intranuclear rodlet immunoreactive for 40 kDa huntingtin associated protein and ubiquitin in the mouse brain Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase Neuronal Mitophagy in Neurodegenerative Diseases Role of Rab GTPases in membrane traffic and cell physiology Is Huntingtin Dispensable in the Adult Brain?Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro.Protein networks supporting AP-3 function in targeting lysosomal membrane proteins.Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest Membrane identity and GTPase cascades regulated by toggle and cut-out switches.Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes.Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders.Rab proteins implicated in lipid storage and mobilization.Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database Does Huntingtin play a role in selective macroautophagy?Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.Rab proteins and the compartmentalization of the endosomal system Identification of siRNA delivery enhancers by a chemical library screen.Huntingtin facilitates dynein/dynactin-mediated vesicle transport.Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.

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Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.

http://www.wikidata.org/entity/Q30480364

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2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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Huntingtin-HAP40 complex is a ...... lated in Huntington's disease.

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Journal of Cell Biology

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Huntingtin-HAP40 complex is a ...... lated in Huntington's disease.

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P2093

Anna Shevchenko

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Arun Pal

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Barbara Lommer

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Fedor Severin

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Marino Zerial

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P2860

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease

Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B

Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

Characterization of a cis-Golgi matrix protein, GM130

Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

Rab proteins as membrane organizers

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

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4

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172

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7299774

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16476778

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Huntington disease

Coagulation factor VIII associated 2

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2063679

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