Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. - Wikidata - awgldk - TriplyDB

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

http://www.wikidata.org/entity/Q30692017

about

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane Radixin assembles cAMP effectors Epac and PKA into a functional cAMP compartment: role in cAMP-dependent cell proliferation Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.Role of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiology cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling.The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.Direct spatial control of Epac1 by cyclic AMP.Epac, not PKA catalytic subunit, is required for 3T3-L1 preadipocyte differentiation.Early transcription from the maternal genome controlling blastomere integrity in mouse two-cell-stage embryos.Pseudoscaffolds and anchoring proteins: the difference is in the details.AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS).Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion Isoform-specific antagonists of exchange proteins directly activated by cAMP Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.Epac and PKA: a tale of two intracellular cAMP receptors.EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain.Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages.Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2 Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.

P2860

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P2860

Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP.

http://www.wikidata.org/entity/Q30692017

description

2002 nî lūn-bûn

@nan

2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

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2002年論文

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2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@ast

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@en

type

label

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@ast

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@en

prefLabel

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@ast

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@en

P1433

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P1476

Q30692017-1E969597-5A7C-4156-BD3F-2685AFA6915A

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P2860

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P356

P1433

Journal of Biological Chemistry

P1476

Cell cycle-dependent subcellul ...... or directly activated by cAMP.

@en

P2093

Fang C Mei

http://www.w3.org/2001/XMLSchema#string

Jingbo Qiao

http://www.w3.org/2001/XMLSchema#string

Leoncio A Vergara

http://www.w3.org/2001/XMLSchema#string

Vsevolod L Popov

http://www.w3.org/2001/XMLSchema#string

Xiaodong Cheng

http://www.w3.org/2001/XMLSchema#string

P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain

A ras-related gene with transformation suppressor activity

Signaling through scaffold, anchoring, and adaptor proteins

Cytoplasmic dynein as a facilitator of nuclear envelope breakdown

Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells

Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

P304

26581-26586

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scholarly article

P356

10.1074/JBC.M203571200

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P407

P433

29

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P478

277

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P577

2002-05-08T00:00:00Z

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11369709

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P698

12000763

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